Prescription divination is a traditional type of folk healing since early Taiwan community. The prescription is generally composed of Chinese medicine after ritual processing and providing a particular treatment result. How prescription divination response to medical needs from people? What is the role of Chinese medicine during the healing action of prescription divination? This research is applied literature review and fieldwork of medical anthropology to pursue the origins. Further discussion is tried to determine the relationship between Chinese medicine and prescription divination especially chronological and geographic changes.