Features of Oral Cancers in Taiwanese Females with Free Tissue Transfers: Based on NTUH Data

經游離皮瓣重建之台灣女性口腔癌之特色：國立臺灣大學醫學院附設醫院之經驗

陳思恆(Shih-Heng Chen) ； 陳宏基(Hung-Chi Chen) ； 楊銘欽(Ming-Chin Yang) ； 謝榮賢(Jung-Hsien Hsieh) ； 戴浩志(Hao-Chih Tai) ； 洪學義(Shyue-Yih Horng) ； 陳明庭(Ming-Ting Chen) ； 湯月碧(Yueh-Bih Tang)

《中華民國整形外科醫學會雜誌》 18卷4期 (2009/12) Pp. 311-320

https://doi.org/10.7096/JPSA.200912.0311

摘要

Background:
In Taiwan, cancer is the leading cause of death, and oral cancer accounts for the 6th leading cause of cancer death. Most of oral cancer patients are male. However, female patients have different demographic background (such as betelnut, alcohol, and cigarette use) from males, and few studies have focused on the disease character, reconstructive methods, and prognosis of the female patients.
Aims and Objectives:
This study is designed to identify the gender difference of oral cancer, including the disease presentation, subsequent reconstructive modalities, and survival analysis.
Materials and Methods:
From 2002 to 2007, 21 female and 318 male oral cancer patients were included in this retrospective study. Statistical analysis was focused on the gender difference of premorbid conditions, adverse habits, tumor location and laterality, staging, reconstructive procedures and complications, and survival on follow-ups. The nasopharyngeal cancer was excluded.
Results:
As for the demographic background, there is no gender difference in the age of disease-onset and underlying diseases. But the females have significantly lower rate of habitual use of cigarettes (p＜0.0001), betelnuts (p＜0.0001), and alcohol (p=0.0029). As for the location of the disease, the males have significantly more buccal cancers (p＜0.0001), and the females have significantly more tongue cancers (p＜0.0001). In addition, the females have more percentage of bilateral disease (p=0.0125). Though the females have better survival and lower recurrence rate, it did not reach statistical significance. There is also no significant difference between two genders in the reconstruction modality, flap size, and postoperative complications. However, more percentage of females than males underwent revisional procedures for cosmetic concerns, which reaches statistical significance (p=0.0125).
Conclusion:
There is no significant gender difference among oral cancer patients in disease recurrence, suvival, flap selection and size, and post-reconstruction complications. However, the female group have less percentage of habitual use of cigarette, alcohol, and betelnuts. The males have significantly more buccal cancers, and the females have more tongue cancers. For the females, aesthetics is a more serious problem than the male patients. Careful selection of donor site and proper design are mandatory.

並列摘要

Background:
In Taiwan, cancer is the leading cause of death, and oral cancer accounts for the 6th leading cause of cancer death. Most of oral cancer patients are male. However, female patients have different demographic background (such as betelnut, alcohol, and cigarette use) from males, and few studies have focused on the disease character, reconstructive methods, and prognosis of the female patients.
Aims and Objectives:
This study is designed to identify the gender difference of oral cancer, including the disease presentation, subsequent reconstructive modalities, and survival analysis.
Materials and Methods:
From 2002 to 2007, 21 female and 318 male oral cancer patients were included in this retrospective study. Statistical analysis was focused on the gender difference of premorbid conditions, adverse habits, tumor location and laterality, staging, reconstructive procedures and complications, and survival on follow-ups. The nasopharyngeal cancer was excluded.
Results:
As for the demographic background, there is no gender difference in the age of disease-onset and underlying diseases. But the females have significantly lower rate of habitual use of cigarettes (p＜0.0001), betelnuts (p＜0.0001), and alcohol (p=0.0029). As for the location of the disease, the males have significantly more buccal cancers (p＜0.0001), and the females have significantly more tongue cancers (p＜0.0001). In addition, the females have more percentage of bilateral disease (p=0.0125). Though the females have better survival and lower recurrence rate, it did not reach statistical significance. There is also no significant difference between two genders in the reconstruction modality, flap size, and postoperative complications. However, more percentage of females than males underwent revisional procedures for cosmetic concerns, which reaches statistical significance (p=0.0125).
Conclusion:
There is no significant gender difference among oral cancer patients in disease recurrence, suvival, flap selection and size, and post-reconstruction complications. However, the female group have less percentage of habitual use of cigarette, alcohol, and betelnuts. The males have significantly more buccal cancers, and the females have more tongue cancers. For the females, aesthetics is a more serious problem than the male patients. Careful selection of donor site and proper design are mandatory.

並列關鍵字

oral cancer ； gender difference ； female ； reconstruction