Sturge-Weber Syndrome Associated with Auditory Hallucination

Sturge-Weber症候群併發聽幻覺

陳頌威(Sung-Wei Chen) ； 孫讚福(Tzan-Fu Sun) ； 呂鎮中(Chun-Chung Lui) ； 張明永(Mian-Yoon Chong)

《台灣精神醫學》 20卷4期 (2006/12) Pp. 321-327

https://doi.org/10.29478/TJP.200612.0009

摘要

目的：Sturge-Weber症候群是先天性神經皮膚疾病，其特徵為軟腦膜血管瘤、青光眼及臉部血管瘤。目前無該症候群出現聽幻覺之案例。我們報告一個案在大腦漸進性鈣化與萎縮後出現聽幻覺。病例報告：三十三歲患有該症候群女性，於二十四歲出現妄想且於二十八歲出現聽幻覺。幻覺出現之前與之後的電腦斷層掃描顯示，左側顯葉有漸進性鈣化與萎縮。神經生理與心理測驗亦確認該腦區有功能缺損。經兩年追踩，每日四毫克劑量的risperidone可改善幻覺且有耐受性。結論：在左側顯葉或額葉受影響的情況下，鈣化與萎縮之漸進性腦病變可解釋聽幻覺的發生。

關鍵字

聽幻覺 ； 精神病症狀 ； 神經皮膚疾病 ； Sturge-Weber症候群

並列摘要

Objective: Sturge-Weber syndrome (SWS) is a congenital neurocutaneous disorder characterized by leptomeningeal angiomatosis, glaucoma, and facial hemangioma. Auditory hallucinations (AH) have not been previously reported in SWS. We report a patient who developed AH after the development of progressive calcification and atrophy of the brain. Case Report: A 33-year-old woman with SWS developed persecutory delusion at 24 years old and AH at 28 years old. Progressive calcification and atrophy of the left temporal lobe were revealed in the series of computed tomography (CT) before and after development of AH. Functional impairment in these areas was verified by neurophysiological and neuropsychological tests. Treatment with 4 mg risperidone daily provided relief for AH and was well tolerated during two years of follow up. Conclusion: It is suggested that progressive brain lesions with calcification and atrophy could account for the development of AH, in cases involving the left temporal or frontal lobes.

並列關鍵字

auditory hallucination ； psychosis ； neurocutaneous disorder ； Sturge-Weber syndrome

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