Acute Kidney Injury in a Patient with Mantle Cell Lymphoma-Associated Hypocomplementemia

被套細胞淋巴瘤合併腎損傷與補體低下血症

吳佳叡(Chia-Jui Wu) ； 邱炳芳(Ping-Fang Chiu) ； 林敬業(Chin-Ye Lin) ； 陳美玲(Mei-Ling Chen)

《The Changhua Journal of Medicine》 14卷1期 (2016/03) Pp. 30-36

https://doi.org/10.6501/CJM.1401.005

摘要

被套細胞淋巴瘤(MCL) 合併腎臟淋巴浸潤是一種罕見的表現。我們報導一位54歲男性，同時合併MCL、急性腎損傷、異常高的抗核抗體跟低補體血症。經由同時實施腎臟、淋巴結跟骨髓切片，皆表現出cyclin D1 來證實診斷。腎臟超音波發現腎臟尺寸變大，而腎臟切片顯示出淋巴型浸潤於腎小管間質，並且表現出跟在骨隨和淋巴結一樣的細胞標記。我們所提出的這位病患，經過徹底文獻搜索後，是第一位同時合併MCL、異常高的抗核抗體跟低補體血症與急性腎損傷。

關鍵字

急性腎損傷 ； 低補體血症 ； 被套細胞淋巴瘤

並列摘要

Lymphomatous infiltration of the kidney is a rare manifestation of mantle cell lymphoma (MCL). We present the case of a 54-year-old male with MCL, acute kidney injury, extremely high antinuclear antibody titers, and hypocomplementemia. The diagnosis of MCL was further confirmed by kidney, lymph node, and bone marrow biopsies and immunohistochemical analysis of cyclin D1 expression. Renal ultrasonography demonstrated bilateral renal hypertrophy, and histological examination of renal biopsy revealed lymphomatous infiltration of the tubulointerstitium, with similar antigenic profiles to those observed in bone marrow and lymph node samples. Following a thorough literature search, we believe the present case represents the first report of MCL with abnormally high antinuclear antibody titers, hypocomplementemia, and acute kidney injury.

並列關鍵字

acute kidney injury ； hypocomplementemia ； mantle cell lymphoma