This case is a Yellow-margined box turtle had an open wound at lateral neck after placing esophagostomy tube. Because the wound was on an awkward location, dressing couldn't be properly placed, the wound was deteriorated and non-healing. After using modified tie-over bandage in concert with debridement under anesthesia, systemic antibiotics, appropriate husbandry, nutrition support and regular dressing change, the wound gradually healed, and patient recovered. This bandage method is modified from tie-over bandage, it can be used in reptilian wounds that are hard to bandage in the future.