Ankylosing Spondylitis is a disease with an inf1ammatory process involving axial skeletal joints and major peripheral joints. When the destrnction, ankylosis, and deformation of the joints are severe, surgical intervention may be indicated to restore the function and to correct the deformity of the joints. Total hip replacement, a current standardized procedure for end-stage hip disorder, provides elimination of discomfort, correction of flexion contracture and restoration of the range of motion for arthritic hips affected by ankylosing spondylitis which is unresponsive to conservative treatment. Three kinds of spinal osteotomies, Smith-Peterson osteotomy, multiple-level osteotomy, transpedicular wedge osteotomy, have been used to correct the kyphotic deformity of the thoracolumbar in patients with ankylosing spondylitis. Deformities of more than 50° or intractable back pain due to spondylodiscitis are indications for those procedures. Kyphotic deformity of the cervical spine can also be corrected through a conventional C7 osteotomy or the Halo-distraction technique.