The decision of withdrawing life-sustaining treatment may arise in any clinical situation. As to our literature review for life-sustaining treatment, we found that most of the withdrawal of life-sustaining treatment was performed in the intensive care unit. We shared our experience of two non-cancer terminally ill patients who underwent withdrawing life-sustaining treatment in palliative care unit. According to previous studies, there were three aspects that needed to be concerned: factors influencing the decision to withdraw life-sustaining treatment, early assessment of palliative medical needs for terminally ill patients and preparations before and after withdrawal of life-sustaining treatment. Based on our clinical care experience and previous studies, we hope that the wish of peaceful dying in the future will be less constrained by place and time, and it would be more adaptable to various clinical situations.