As disease patterns have shifted towards a high prevalence of chronic diseases in these years, the quality of health is heavily influenced by lifestyle habits and self care management. Patients’ inadequate compliance is a pervasive and serious problem. It worsens health conditions and raises medical costs. By promoting their health behavior, patients can live longer and healthier and contain health costs. Although the health care system has persistently emphasized patients' health education, the increased knowledge of patients may not represent the better compliance. Over past three decades, self-efficacy perspectives have been successively applied in health fields. The conceptual model posits a multifaceted causal structure in which self-efficacy beliefs operate together with outcome expectations and goals in the regulation of human motivation, behavior, and well-being. In many existing studies, self-efficacy and outcome expectations are recognized as strongest predictors of health behavior change. Meanwhile, research of interventions incorporating the four specific efficacy-enhancing techniques of facilitating personal mastery, vicarious experiences, identifying distress and providing verbal persuasion have demonstrated lower levels of health care consumption and improved psychosocial adjustment to a new health status. These concepts provide scientific evidence base for health promotion strategies. In this paper, we review the related literature and conceptual framework. Finally, concrete self-managed interventions of chronic diseases based on the predictors of self-efficacy perspectives are suggested.