Supernumerary teeth (STs) in children may cause delayed eruption or malocclusion or may even develop into a cyst. Recent reviews suggest early removal of unerupted STs. However, locating the target teeth and avoiding damage to adjacent permanent teeth and vital tissues are major concerns in early treatment. We present the case of a 10-year-old boy with five STs over four quadrants of the canine-premolar area. Surgical removal of all STs was performed under general anesthesia with a dynamic surgical navigation system (DSNS). The surgery proceeded without complications, and the patient recovered well. Early ST removal surgery in children is challenging. Therefore, a DSNS represents a promising solution and a minimally invasive intervention for multiple STs.