Teratogenic Effects of Two New Derivatives of Quinazolinones on Balb/C Mice Embryos and Newborns: A Literature Review

Hadis Gholipour ； Maryam Shams Lahijani

《Current Research Journal of Biological Sciences》 9卷2期 (2017/10) Pp. 23-31

https://doi.org/10.19026/crjbs.9.5139

摘要

Teratogens are medicines or chemical factors which can affect various stages of organogenesis, change normal cell growth, induce abnormalities and create several defects. Therapeutic use of multiple drugs causes lots of concerns about injuries to the embryos/newborns. The aim of this study was to focus on the impact of two derivatives of quinazolinones including 4(3H)-quinazolinone-2-propyl-2-phenylethyl) (QPPE)and 4(3H)- quinazolinone-2-ethyl-2-phenyl ethyl (QEPE), as heterocyclic compounds with biological and pharmaceutical properties at different levels including morphological, skeletal, histological, cellular, biochemical and genetic aspects of embryos and newborns of Balb/C mice in crucial days of differentiations and organogenesis. These investigations have been done at the Faculty of Sciences (Developmental Biology, Animal Sciences), University of Shahid-Beheshti(SBU) in this field for many years. This literature review expresses and interprets the devastating effects of these compounds, such as abnormal and underdeveloped embryos, abnormal placenta, necrosis in many organs, splenomegaly, apoptosis in testes and ovary, deformed nucleoli, Damaged mitochondria, change in the level of alkaline phosphatase and many other injuries.

關鍵字

Anomalies ； embryo ； mice ； newborn ； quinazolinone ； teratogen