Anti-Inflammatory, Antipyretic and Anti-Nociceptive Activities of the Ethanol Stem Bark Extract of Salacia lehmbachii

A.D. Essien ； EdidaraE. Thomas ； Grace A. Essiet ； G.C. Akuodor

《British Journal of Pharmacology and Toxicology》 8卷2期 (2017/10) Pp. 9-16

https://doi.org/10.19026/bjpt.8.5284

摘要

The aim of this study is to scientifically elucidate the effects of Ethanol Stem Bark Extract (ESBE) on inflammation, pyrexia and pains induced in rats and mice, following the claim that decoction from stem-bark of Salacia Lehmbachii (SL) is used in treating feverish and painful conditions in south-eastern parts of Nigeria. The anti-inflammatory activities of the ESBE of this plant were studied, using carrageenan and egg albumin-induced paw edemain albino Wistar rats; and antipyretic activities were examined, using Dinitrophenol and Brewer's yeast-induced pyrexia in Wistar rats, while acetic acid- induced writhing and tail immersion models were used for analgesic study. LD_(50) and ED_(50) of the ESBE were carried out to determine its safety and dosing regimen, respectively. Thirty animals were randomly selected and grouped into five with six animals per group for each experiment. Group 1 and 5 (controls) received 20 mL/kg of distilled water and 150 mg/kg of aspirin and 10 mg/kg of morphine (tail immersion study) respectively; while groups 2 to 4 received 75, 150 and 300 mg/kg of the extract respectively. The ED_(50) was 150 mg/kg. The ESBE of SL exhibited significant (p＜0.05) dose related effects in all the experimental models. Doses of 150 and 300 mg/kg abolished the induced edema, induced pyrexia and pains, highly comparable to respective positive controls. Therefore, ESBE of Salacia lehmbachii possesses potent antiinflammatory, antipyretic and analgesic activities, likely resulting from its phytochemical constituents. Hence, its folkloric use in herbal medicines for pains and fever is justified.

關鍵字

Dinitrophenol ； inflammation ； nociception ； pyrexia ； Salacia lehmbachii-stem bark ； tail-immersion