- 期刊
- OpenAccess
Altered Functional Connectivity in the Basal Ganglia Network and Executive Network in Parkinson's Disease Patients With Impulse-Control Disorder
摘要
PURPOSE. Impulse-control disorder (ICD) is one of the most debilitating symptoms in Parkinson's disease (PD). The development of such a disorder is partially attributed to dopaminergic medications. Studies have shown more structural and functional brain alterations in PD patients with impulse-control disorder (PD-ICD) compared to PD patients without ICD. In this study, we aimed to investigate the differences in brain networks among PD-ICD, PD without ICD, and normal control subjects. MATERIALS AND METHODS. In total, 28 PD patients (8 PD-ICD patients and 20 PD patients without ICD) and 22 sex- and age-matched healthy subjects were enrolled. Detailed neuro-psychological testing using the Wechsler Adult Intelligence Scale-III, Cognitive Abilities Screening Instrument, and magnetic resonance imaging (MRI) 3.0 Tesla GE Signa whole-body MRI system was conducted for all subjects. Resting state network assessments for basal ganglia and bilateral executive control networks were analyzed among different groups and medication status. RESULTS. PD patients without ICD had decreased functional connectivity (FC) over their basal ganglia networks compared to normal controls, while the PD-ICD group did not show such a difference. PD-ICD patients exhibited increased FC in the right executive control network compared to healthy controls, regardless of medication status, and the FC in the right executive control network in PD patients without ICD was found to be affected by medication. CONCLUSION. In this study, we found distinct network differences between PD-ICD and PD without ICD patients in the basal ganglia and executive networks. These network differences may contribute to their different clinical presentations.
延伸閱讀
- Ding, K., Liu, Y., Yan, X., Lin, X., & Jiang, T. (2013). Altered Functional Connectivity of the Primary Visual Cortex in Subjects with Amblyopia. Neural Plasticity, 2013(), 400-407. https://doi.org/10.1155/2013/612086
- Demetriades, P., Rickards, H., & Cavanna, A. E. (2011). Impulse Control Disorders Following Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease: Clinical Aspects. Parkinson＇s Disease, 2011(), 551-559. https://doi.org/10.4061/2011/658415
- 周郁玹（2019）。Connectome analysis of brain functional network alterations in depressed patients with suicide attempt and ideation〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU201900151
- Murphy, E. R., Feig, J. F., Kenworthy, L., Gaillard, W. D., & Vaidya, C. J. (2012). Atypical Functional Connectivity of the Amygdala in Childhood Autism Spectrum Disorders during Spontaneous Attention to Eye-Gaze. Autism Research and Treatment, 2012(), 159-170. https://doi.org/10.1155/2012/652408
- Trojsi, F., Monsurrò, M. R., Esposito, F., & Tedeschi, G. (2012). Widespread Structural and Functional Connectivity Changes in Amyotrophic Lateral Sclerosis: Insights from Advanced Neuroimaging Research. Neural Plasticity, 2012(), 549-561. https://doi.org/10.1155/2012/473538