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Immunoglobulin G4-Related Lung Disease Presenting With Multiple Solid and Subsolid Nodules: A Case Report

摘要


Immunoglobulin G4 (IgG4)-related disease features the proliferation of IgG4-positive plasma cells and lymphocyte infiltration accompanied with fibrosis in target organs. The presentations of IgG4-related lung disease in imaging are variable, with manifestations of solid nodules, round ground-glass opacities, alveolar interstitial cells, and bronchovascular patterns caused by inflammation along the entire intrapulmonary connective tissue reported in the literature. We report a case of IgG4-related lung disease manifesting as multiple solid and subsolid nodules in the bilateral lungs. Initial imaging differential diagnoses were broad, with the final diagnosis produced on the basis of the pathologic examination of obtained specimens via wedge resection.

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