Medication administration delays in hospitals increase hospital expenses, raise mortality rates, and reduce patient satisfaction. Data was collected for this study through on-site observations and an information management program. It was found that nurses’ rate of medication administration delays is as high as 21% due to several interferences during the administration process. Of these interferences, nurse-patient communication is the major reason for delays. This is followed by poor preparation of operation vehicles, IV set problems and poor doctor-nurse communication. The interference of medication administration delay can be reduced from 21% to 10.5% by the following actions: 1. establishing a standard medication-dispensing protocol 2. broadcasting before medication administration 3. supplementing operation vehicle materials 4. preparing self-medication reminder cards 5.IV instruction cards and 6. telephone messages. Medication administration delays were effectively reduced by these measures, improving the quality of care. We suggest implementing these methods in other acute care units.