金屬催化試劑媒介碳－氫鍵活化策略於有機合成上的應用

Transition Metal-Mediated Carbon-Hydrogen Bond Activation Strategy Applied in Organic Synthesis

朱見和(Jean-Ho Chu) ； 蘇哲弘(Zhe-Hong Su) ； 晏可旺(Ko-Wang Yen)

《化學》 78卷4期 (2020/12) Pp. 309-321

https://doi.org/10.6623/chem.202012_78(4).005

摘要

碳－氫鍵是有機分子結構中常見且廣泛分佈的化學鍵結，分子因其高度反應惰性而能於正常狀態下穩定存在；然而此特性往往也是導致分子難以進行化學轉化的主因。對化學家而言，如果能夠擁有高效率且簡易的方法直接將特定碳－氫鍵進行轉化，這會是相當理想的有機合成方法；再者就原子轉化經濟層面來看，此種合成方式更能夠符合綠色化學之期望原則。目前化學家已經成功利用過渡金屬試劑催化惰性碳－氫鍵進行活化反應暨結構轉化。本文內容將就過渡金屬媒介碳－氫鍵活化之簡要歷史、反應機制以及此策略於有機合成上之應用例子作詳細介紹。

關鍵字

過渡金屬催化碳－氫鍵活化反應 ； 導向基團 ； 有機合成

並列摘要

The carbon-hydrogen bond is widely distributed in organic molecules and owns highly chemical inertia. In nature, most organic molecules can stably exist under normal conditions because of the feature. However, it also causes chemical modification much difficulty. The transition metal-mediated carbon-hydrogen bond activation enables organic synthesis to become more efficient. Meanwhile, this synthetic strategy can satisfy the requirement of green chemistry in terms of the atom economy. Now, the chemist has successfully realized the direct carbon-hydrogen bond functionalizations and transformations by employing transition metals as catalysts. This review briefly introduces the historical development of the carbon-hydrogen bond activation, types of reaction mechanisms, and its synthetic applications.

並列關鍵字

Transition metal-catalyzed C-H bond activation ； Directing group ； Organic synthesis