With the publication of the Outline of the Development Plan for the Guangdong-Hong Kong-Macao Greater Bay Area, the importance of science and technology education in the Guangdong-Hong Kong-Macao Greater Bay Area has become increasingly apparent. In view of the current problems in the education of Guangdong, Hong Kong and Macao science and technology museums, this paper attempts to analyze the birth and development of the science and technology venues alliance, and analyze the representative Guangdong Science Center, Hong Kong Science Museum and Macao Science Center in Guangdong-Hong Kong-Macao Greater Bay Area Science and Technology Museum Alliance. Resources for educational activities, and from the research of science and technology museum researchers, primary and secondary school teachers, primary and secondary school students and the public, the implementation of educational activities resources integration in Guangdong-Hong Kong-Macao Greater Bay Area Science and Technology Museum. Finally, the possible problems in the construction of resource integration put forward thinking.