As an international tourism city, Macao's tourism management higher education combines local industrial characteristics with international tourism in a cross-cultural social environment. It can provide reference to college tourism management courses for mainland tourism destinations. At the same time, the content of the course in the design of the undergraduate course of tourism management should be given corresponding attention in the higher education in Macao, and improved on the basis of student feedback. The research on the undergraduate course design of tourism management under the cross-cultural background is conducive to the further improvement of the talent training program in the Guangdong-Hong Kong-Macao greater bay area.