As an important channel for land-sea connection, the submarine pipeline is a link for offshore oil and gas development. Third-party activities are one of the important risk sources of submarine pipeline damage, and relevant scholars have researched this. With the diversification of marine development activities, the safety assessment of submarine pipelines by third-party activities must also keep pace with the times. Based on the analysis of the third-party risk factors of submarine pipelines by predecessors, this paper summarizes the current human activities at sea and divides these into three categories: water transportation and transportation, marine development and utilization, and fish farming and fishing. It discussed the mutual influence of various maritime activities on submarine pipelines and improved the investigation content system for preventing third-party sabotage of submarine pipelines. And taking a submarine pipeline as an example, the system is applied to the investigation of the third-party damage prevention of submarine pipelines. The third-party marine development activities affecting the operation and maintenance of submarine pipelines were classified and evaluated. The regional distribution of pipeline routing risks was proposed. The evaluation results have significant reference value for the planning, design, operation, and maintenance of submarine pipelines.