The National Networking of Manufacturing Innovation strategy is an important development plan that affects the "re-industrialization" strategy of the United States. Since its implementation in 2012, it has achieved remarkable results and opened up new advantages of manufacturing innovation. In this paper, the background, development process, operation mode and effectiveness of the strategy of "National Networking of Manufacturing Innovation" in the United States are deeply analyzed. On this basis, combined with the current situation of China's manufacturing industry development, suggestions are put forward to promote the development of China's manufacturing industry.