通過改變分子探針的折射性質檢測水溶液中的鈷離子

本篇研究利用分子探針的折射性質變化建立了一種可檢測水溶液中的鈷離子的方法。使用的分子4'-2-(mercaptoethyl)-(1,1'-biphenyl)-4-carbonitrile (TAT-12)，是參考liquid crystal based-sensors常使用的液晶分子5CB (4-Cyano-4'-pentylbiphenyl)，將5CB的軟鏈端修改為硫醇，預期硫醇會與金屬離子配位，並改變TAT-12在偏光顯微鏡（POM）下的光學性質。我們發現TAT-12在室溫下為固態，並且在含有鈷離子的溶液中混合後會產生一新分子，透過NMR、質譜及根據過去的研究發現此分子是經鈷離子催化所產生之二聚體。由於折射率的不同，可簡易的利用亮度的變化來判斷溶液中是否含有鈷離子，不須判讀相對複雜的訊號來檢視結果。我們進行了選擇性、靈敏度和真實樣品的檢測，並研究了TAT-12如何檢測水溶液中的鈷離子。

關鍵字

折射率；鈷離子；檢測器

並列摘要

In this study, a method for detecting cobalt ions in aqueous solutions was established by using changes in the refractive properties of molecular probes. The molecule 4'-(2-mercaptoethyl)-(1,1'-biphenyl)-4-carbonitrile (TAT-1) used in this study is a reference to the liquid crystal molecule commonly used in liquid crystal based-sensors, 5CB (4-Cyano-4'-pentylbiphenyl), the soft chain end of 5CB is modified to thiol, it is expected that sulfur will coordinate with metal ions and change the optical properties of TAT-12 under polarized light microscope (POM). We found that TAT-12 is a solid at room temperature and will produce a new molecule after mixing in a solution containing cobalt ions. Through NMR, mass spectrometry and past studies, we have found that this molecule is a dimer produced by cobalt ion catalysis. Since the refraction properties are obviously different, the change in brightness can be easily used to determine whether the solution contains cobalt ions, and there is no need to interpret relatively complicated signals to check the results. We carried out the detection of selectivity, sensitivity and real samples, and studied how TAT-12 can detect cobalt ions in aqueous solutions.