一系列2-苯乙烯色酮衍生物的合成

Synthesis of a series of 2-styrene chromone derivatives

林恆蔚(Heng-Wei Lin)

指導教授 ： 施增廉

淡江大學/理學院/化學學系碩士班/碩士(2021年)

https://doi.org/10.6846/TKU.2021.00614

摘要

本文內容主要為一系列苯乙烯色酮的合成，苯乙烯色酮化合物在抗癌的功效上具有相當良好的潛力，因此利用合成方式能以更有效率的方式取得苯乙烯色酮化合物，並且能在官能基上做不同的改變，並跟慈濟大學及國立陽明交通大學研究，發展其他的生物活性；本文所合成的方向為苯乙烯色酮B環上官能基的改變，其中一衍生物2-(2-吡啶)苯乙烯色酮也會測試其質子化程度的不同下，所激發出的螢光改變，探討其是否在生物螢光探針上具有潛力。

關鍵字

苯乙烯色酮 ； 生物活性 ； 螢光探針

並列摘要

The content of this article is mainly about the synthesis of a series of styrene chromones. Styrene chromone compounds have quite good potential in anti-cancer efficacy. Therefore, the use of synthetic methods can obtain styrene chromone compounds in a more efficient manner, and can Make different changes in the functional group, and study with Tzu Chi University and National Yangming Jiaotong University to develop other biological activities; the direction of synthesis in this article is the change of the functional group on the B ring of styrene chromone, one of which is a derivative 2 -(2-Pyridine) styrene chromone will also test the changes in fluorescence induced by its protonation degree, and explore whether it has potential in bioluminescent probes

並列關鍵字

2-styrene chromone ； biological activity ； fluorescent probe

參考文獻

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