維生素B-6介入對代謝症候群者的血漿同半胱胺酸濃度、發炎反應及脂質過氧化的影響

研究指出維生素B-6可降低同半胱胺酸濃度、發炎反應及脂質過氧化程度。因代謝症候群者經常處於血脂異常及發炎前期狀態，因此本研究目的是探討維生素B-6補充劑的介入是否能增加代謝症候群者的血漿磷酸比哆醛濃度進而降低血漿同半胱胺酸、發炎反應指標或脂質過氧化程度。本研究對象自台中中山醫學大學附設醫院新陳代謝科募集符合行政院衛生署國民健康局公佈之代謝症候群定義 50位代謝症候群受試者，以隨機的方式分派為二組，分別給予安慰劑 (n = 24) ，或100 mg/d的維生素B-6 (n = 26) ，介入12週，分別在第0、4、8及12週進行受試者體位測量、臨床血液生化值、血漿維生素B-6 (磷酸比哆醛、4-比哆酸) 、尿液比哆酸、血漿同半胱胺酸、發炎反應指標 (高敏感度C-反應蛋白、白細胞介素-6、纖維蛋白) 及脂質過氧化指標 (氧化型低密度脂蛋白、硫代巴比妥酸反應物) 的分析。研究結果顯示維生素B-6介入12週後，對降低血漿同半胱胺酸濃度並無顯著作用。但是，增加1 nmol/L磷酸比哆醛濃度，可顯著降低0.001 pg/mL白細胞介素-6 (IL-6,= -0.001, p < 0.05) 及0.020 mU/L的氧化型低密度脂蛋白 (ox-LDL,= -0.020, p < 0.01) 。本研究結果顯示給予維生素B-6補充劑的介入雖然對降低禁食血漿同半胱胺酸濃度無顯著效果，但卻可降低代謝症候群者的發炎反應 (IL-6) 及脂質過氧化 (ox-LDL) 狀態。

關鍵字

維生素B-6 ；同半胱胺酸；脂質過氧化；發炎反應；代謝症候群

並列摘要

Metabolic syndrome has been recognized as abnormal lipid and pro-inflam¬matory status. It has been reported that vitamin B-6 could decrease plasma homocysteine concentration, inflammatory response, and lipid peroxidation. The purpose of this study was to investigate whether vitamin B-6 supplement could increase plasma pyridoxal 5’-phosphate (PLP) concentration and further decrease plasma homocyste¬ine concentration, inflammatory responses, and lipid peroxidation in sub¬jects with metabolic syndrome. Fifty subjects were recruited from the Divi¬sion of Metabolism, Chung Shan Medical University Hospital, Tai¬chung and were diagnosed as having metabolic syndrome according to the criteria of Bureau of Health Promotion, Department of Healthy, Tai¬wan, ROC. Subjects were randomly divided into the placebo group (n=24) and the vitamin B-6 group (100 mg/d vitamin B-6) (n=26). At week of 0, 4, 8, and 12, weight and height were measured. Fasting blood sample was ob¬tained to analyze hematological parameters and plasma vitamin B-6 status (PLP; 4-pyridoxic acid, 4-PA). Indicators of inflammatory responses (high sensitivity C-reactive protein; interleukin-6, IL-6, and fibrinogen) and lipid peroxidation (thiobarbituric acid reactive substances, TBARS; oxidized low-density lipoprotein, ox-LDL) were also measured. Results showed that 12 weeks of vitamin B-6 supplementation did not decrease plasma homocysteine concentration. However, IL-6 was significantly decreased by 0.001 pg/mL (= -0.001, p < 0.05) and ox-LDL was decreased by 0.020 mU/L (= -0.020, p < 0.01). Although vitamin B-6 intervention could not decrease fasting plasma homocysteine concentration, it significantly decreased the inflammatory response (IL-6) and lipid peroxidation (ox-LDL) in subjects with metabolic syndrome.

並列關鍵字

vitamin B-6 ； homocysteine ； lipid peroxidation ； inflammatory responses ； metabolic syndrome

參考文獻

行政院衛生署國民健康局。

Chuang SY, Chen CH, Chou P. Prevalence of metabolic syndrome in a large health check-up population in Taiwan. J Chin Med Assoc 2004; 67: 611-20.

Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987; 422: 43-52.

Audet A, Lupien PJ. Triglyceride metabolism in pyridoxine-deficient rats. J Nutr 1974; 104: 91-100.

Bates CJ, Pentieva KD, Matthews N, Macdonald A. A simple, sensitive and reproducible assay for pyridoxal 5’-phosphate and 4-pyridoxic acid in human plasma. Clin Chim Acta 1999; 280: 101-11.

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維生素B-6介入對代謝症候群者的血漿同半胱胺酸濃度、發炎反應及脂質過氧化的影響

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