麩醯胺酸轉胺酶2在乾癬的角色

The role of transglutaminase 2 in psoriasis

林泓科(Hung-ke Lin)

指導教授 ： 蔡嘉哲

中山醫學大學/醫學院/醫學研究所/碩士(2012年)

https://doi.org/10.6834/CSMU.2012.00134

摘要

乾癬是一種免疫系統所引發的炎症皮膚疾病，表現出角質細胞的不正常增生、分化，和血管新生，麩醯胺酸轉胺酶2在乾癬的生理角色尚未被建立。本研究主題主要證實TG2在乾癬皮膚的表現;若是有相關，則進一步探討TG2是否為乾癬病人的臨床表現影響因素。本研究採回溯性，非盲，非隨機分派的方式，收集37例乾癬病人的皮膚切片，以免疫組織化學染色方法進行TG2染色，並分析臨床表現的相關性。研究結果發現所有37例病理切片皆有染色，其中32例染色強度為強度，5例為低度，22個為早期病灶，15個為晚期病灶，染色的部位全部在上皮層，從基底層以上，染色強度由下而上遞減，但同一個病人的非病灶處的皮膚則只在基底層有染色。患病時間，乾癬次分型，與疾病分期和TG2之表現無相關性。本研究證實TG2參與乾癬的病理過程，但臨床意義尚需進一步確認。

關鍵字

乾癬 ； 麩醯胺酸轉胺酶2 ； 皮膚切片 ； 免疫組織化學染色

並列摘要

Psoriasis, a inflammatory skin disease triggered by immune system, presents keratinocyte hyperproliferation, differentiation, and angiogenesis. The role of TG2 in psoriasis has not been established yet. The retrospective, non-randomized, and, non-blinding study collected skin biopsy from 37 psoriasis patients and performed immunohistochemical staining. TG2 antibody deposit were found in all the 37 samples, and among which 32 were strong, 5 weak staining, 22 in early and 15 in late stage. They located in epidermis, spreading from basement layer to striatum conium in decrease pattern. In non-lesion site of psoriasis, the stain was only in basement layer. The presence of TG2 was not associated with disease duration, stage of disease and subtype of psoriasis. TG2 participated in the pathogenesis of psoriasis, yet the clinical relevance need further study.

並列關鍵字

psoriasis ； transglutaminase 2 ； skin biopsy ； immunohistochemical stain

參考文獻

1. Naldi, L., Epidemiology of psoriasis. Curr Drug Targets Inflamm Allergy, 2004. 3(2): p. 121-8.

2. Tsai, T.F., et al., Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan. J Dermatol Sci, 2011. 63(1): p. 40-6.

3. Farber, E.M. and M.L. Nall, The natural history of psoriasis in 5,600 patients. Dermatologica, 1974. 148(1): p. 1-18.

4. Setty, A.R., G. Curhan, and H.K. Choi, Smoking and the risk of psoriasis in women: Nurses' Health Study II. Am J Med, 2007. 120(11): p. 953-9.

5. Setty, A.R., G. Curhan, and H.K. Choi, Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses' Health Study II. Arch Intern Med, 2007. 167(15): p. 1670-5.