血管支架之疲勞行為分析與模擬

Analysis and Simulator on the Fatigue of Cardiovascular Stent

林聖堯(Sheng-Yao Lin)

指導教授 ： 陳政順

國立臺北科技大學/機電學院/機電整合研究所/碩士(2006年)

https://doi.org/10.6841/NTUT.2006.00053

摘要

本研究主要目的是在分析與模擬血管支架的應力、變形與疲勞行為；同時嘗試計算分析血管支架在未植入人體之前，在特定週期負荷作用下的疲勞壽命；由於該模擬分析中可以了解到血管支架在植入人體後，及可能產生的破壞位置點；本研究模擬希望在未來可以做到預防血管支架對人體血管的二次血栓和再堵塞所造成的心肌缺氧、中風等問題。
本研究的方法乃是先會使用三維繪圖軟體畫出不同尺寸的血管支架，然後在根據有限元素法去設定其血管支架的邊界條件和模擬其植入人體後；受到不同的殘留壓力與反覆血液流動的壓力，所造成的最大應力、應變及總變形量之間的關係；同時在由其最大應力值去模擬血管支架，在血管中的疲勞壽命與疲勞損壞位置；然而由以上的模擬結果，可以了解到目前Palmaz-schatz血管支架之使用壽命為109以上；同時也可以知道二次應力集中的位置，在Palmaz-schatz血管支架之肋和肋連接的直角位置。
同時期望該模擬研究之方法和模擬步驟，在未來可以提供給國內的廠商和各研究單位，作為在血管支架上的一個研究性的基礎參考和生物力學之分析，並且更加期望可以幫助國內的廠商，做出適合於國人的血管支架之產品；再者希望未來在健保的完全給付下，可以使用到便宜且實用性高的血管支架。

關鍵字

應力 ； 疲勞 ； 生物力學 ； 血管支架

並列摘要

This main purpose of research is with the simulation stress of the cardiovascular stent , fatigue out of deformed in analysis; Try the cardiovascular stent of computational analysis before implantation into the human body at the same time , the fatigue life under the load function of specific cycle ; Because should simulation and can know while analysing that the cardiovascular stent is after implantation the human body into , and click in the destroy position that may be produced .
This research simulation hopes to make sure to prevent the Cardiovascular stent support to questions , such as thrombus two times of the human Cardiovascular stent and stopping up the apoplexy with meagre oxygen of cardiac muscle caused again ,etc. in the future.
This research method is to use the three-dimensional mapping software to draw the cardiovascular stent of different size first , next is it create their cardiovascular stent boundary conditions and simulation their of support after implantation according to finite element method into the human body to go; Receive different residue pressures and pressure of the repeated blood circulation , greatest stress , meets an emergency and the relation between total deformation amount caused; Being imitated the cardiovascular stent , the position with damage of fatigue life in the blood vessel by its greatest stress value at the same time ; But by the simulation result of the above , can understand that use life of Palmaz-schatz cardiovascular stent has been more than 109 up till now ; At the same time , can know the position where the stress two times concentrates , the right angle position joined in the rib and rib of Palmaz-schatz cardiovascular stent too.
At the same time the expectation should imitate the method to study and simulation step , can offer domestic manufacturer and every research unit in future, as foundation of research consult in previous piece, cardiovascular stent of support and analysis of “Biological Mechanics”, and expect further that be able to help the domestic manufacturer , make the products of the cardiovascular stent support which is suitable for compatriots; Hope future in is it under protect pay totally , can use get cheap and practicability high cardiovascular stent support to strong in moreover

並列關鍵字

Stress ； Fatigue ； Cardiovascular Stent ； Biological Mechanics

參考文獻

28. Pro/Engineer 零件設計進階訓練課程，參數科技股份有限公司。

29. ANSYS Workbench 手冊，虎門科技股份有限公司。

6.藍青，「血管支架與高科技醫療」，健康世界,187(307),pp.72-76,2001。

32. Serruy, P.W. and Kutryk, M.J.B., Handbook of coronary stents, 2nd Edition, Martin Duniz Ltd, London,1998.

7.張天鈞主編、台大醫學院內科醫科合著，「台大內科學講義」，當代醫學，第21卷,3nd Edition 第106~110頁，民國90年3月。