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  • 學位論文

超低溫液態氮生物試片儲存槽改良設計與分析

Design and Analysis of the Biospecimen Storage System with Liquid Nitrogen

指導教授 : 陸元平

摘要


隨著醫學工程的進步,生物試片如幹細胞,臍帶血等的儲存越受重視,經研究發現生物試片存放於攝氏-196℃之液態氮中幾乎可永久保存其活性,而目前市面上其中一種掀蓋式試片儲存槽開蓋後由於桶內外巨大的溫差將導致煙霧瀰漫、試片辨識不易的問題,而本研究之目的為針對傳統式儲存槽上蓋進行機構設計改良,以達到桶外單一存取、編號辨識、精準定位、提升操作安全性(例如:避免液態氮噴濺)、減少液態氮揮發與開蓋導致桶內溫度提升等目的。再利用有限元素分析對模型進行模擬,評估改良設計之安全性、結構穩定性與可能的失效模式,以降低打樣、製造後設計變更的成本浪費。 透過文獻探討了解新型儲存機構的存取方式與儲存槽上蓋的結構,本研究是以新型儲存機構的設計為基礎並改良傳統儲存槽上蓋,以旋轉式上蓋的方式取代傳統式上蓋翻蓋存取的功能且能夠完全配合新型儲存機構的單一存取的功能,改良設計的部分包括上蓋存取口、刻度口、轉動機構、改良轉動把手、試片提取架、推桿等,再利用有限元素模擬分析軟體評估改良設計之安全性與結構穩定度,往後可作為自動化發展或變更設計時之參考依據。從模擬結果可證明旋轉式上蓋確實可配合新型儲存機構且結構穩定,其最大特色為可旋轉上蓋與存取口的設計可完全保留新型儲存機構的試片單一存取功能與優點,能做到桶外試片單一存取、試片刻度精準定位等,解決新型儲存機構於傳統式儲存槽的發展限制亦能擴展新型儲存機構之發展性。

並列摘要


Along with the medicine engineering progress, the biospecimen like stem cell, the umbilical cord blood and so on the storage more receives takes, after research discovery biospecimen depositing in the Celsius - 196℃ liquid nitrogen may nearly permanent preserved its activeness, after raises covers the type store tank to uncap because inside and outside the barrel the huge temperature difference will cause the hazy and the identification not easy preblems. In this study will focus on the mechanical design improvement of the cover of traditional storage tank, and achieve barrel outside single specimen access, number identification, accurate positioning, operational safety, and reduce the volatile of liquid nitrogen during the top cover was opening and temperature rise. Using finite element method simulate the real situation, And evaluate the safety, structural stability, failure modes, and also reduce the waste of costs of the sample making. The rotatable top cover will replace traditional flip top cover and also can fully match the method of the single specimen access. The Improved design includes access port, number port, rotating mechanism, handle, storage rack, putter. Then analyze and evaluate the safety and stability of the improved design, the result of analysis can prove the stability of top cover,and could be a reference for the development of automation or design change. Its biggest feature is the rotatable cover and the access port on the cover, can totally satisfy the function and advantage of the new storage mechanism, and can relieve the restrictions of the new storage mechanism on the traditional storage tank, and expand the development of the new storage mechanism.

參考文獻


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