- 學位論文
ASSOCIATION OF HEPATITIS B VIRUS INFECTION WITH CHRONIC KIDNEY DISEASE IN UNIVERSITY STUDENTS UNDERGOING HEALTH EXAMINATION
ASSOCIATION OF HEPATITIS B VIRUS INFECTION WITH CHRONIC KIDNEY DISEASE IN UNIVERSITY STUDENTS UNDERGOING HEALTH EXAMINATION
摘要
Introduction Taiwan is prevalent of chronic kidney disease (CKD) and an endemic area for chronic hepatitis B virus infection (HBV). There is still inconsistent evidence showing the relationship between CKD and HBV. The cross-sectional study aims to investigate this association among university freshmen in Taiwan. Methods Data from health check-ups for 7,745 university entrants in 2000 – 2001 at a northern university was obtained for this study. Using the modification of diet in renal disease (MDRD) study equation, the estimated glomerular filtration rate (eGFR) was calculated. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between HBV and CKD were estimated by logistic regression. Results The prevalence of HBV and CKD were 7.4% and 6.8% respectively. The prevalence of HBV positive in CKD and non-CKD were not significant (6.0% versus 6.9%, p = 0.42). After adjusting for covariates, the logistic regression analysis for the association of HBV with CKD and low eGFR (<60 ml/min/1.73 m2) show an OR of 0.85 (95% CI = 0.60 – 1.23) and 0.60 (95% CI = 0.30 – 1.24) respectively. Further stratification by sex showed no significant difference with low eGFR. However, males showed an increased risk of CKD (OR = 1.23, 95% CI = 0.76 – 2.00), while females show a decreased risk of CKD (OR = 0.59, 95% CI = 0.34 – 1.02) (interaction test p = 0.06). Conclusion Our results did not support the hypothesis that HBV is associated with increased risk of CKD. Young HBV female carriers tend to possess a protective effect of developing CKD. However, the gender-different risk of CKD needs to be clarified in further larger sample size study.
並列摘要
Introduction Taiwan is prevalent of chronic kidney disease (CKD) and an endemic area for chronic hepatitis B virus infection (HBV). There is still inconsistent evidence showing the relationship between CKD and HBV. The cross-sectional study aims to investigate this association among university freshmen in Taiwan. Methods Data from health check-ups for 7,745 university entrants in 2000 – 2001 at a northern university was obtained for this study. Using the modification of diet in renal disease (MDRD) study equation, the estimated glomerular filtration rate (eGFR) was calculated. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between HBV and CKD were estimated by logistic regression. Results The prevalence of HBV and CKD were 7.4% and 6.8% respectively. The prevalence of HBV positive in CKD and non-CKD were not significant (6.0% versus 6.9%, p = 0.42). After adjusting for covariates, the logistic regression analysis for the association of HBV with CKD and low eGFR (<60 ml/min/1.73 m2) show an OR of 0.85 (95% CI = 0.60 – 1.23) and 0.60 (95% CI = 0.30 – 1.24) respectively. Further stratification by sex showed no significant difference with low eGFR. However, males showed an increased risk of CKD (OR = 1.23, 95% CI = 0.76 – 2.00), while females show a decreased risk of CKD (OR = 0.59, 95% CI = 0.34 – 1.02) (interaction test p = 0.06). Conclusion Our results did not support the hypothesis that HBV is associated with increased risk of CKD. Young HBV female carriers tend to possess a protective effect of developing CKD. However, the gender-different risk of CKD needs to be clarified in further larger sample size study.