摘要
中藥材苦參，為豆科 (Leguminosae) 植物苦參的根。味苦，性寒，有清熱燥濕、袪風殺蟲之功用。根據國內外學者對苦參化學成分的研究發現，在其根中含有生物鹼及黃酮類成分。本實驗以採集自花蓮之苦參根部的甲醇抽出物，以各種色層分析方法 (矽膠管柱層析、Sephadex LH-20及HPLC) 進行分離純化，得到四個新化合物，5,7,2'4'-tetrahydroxy-5'-methoxy-8-lavandulylflavanone (11)、8-lavandulylkaempferol (18)、2-(2',4'-dihydroxy-5'-prenylphenyl)-5,6- methylenedioxybenzofuran (21) 及 2,4,2’,4’-tetrahydroxy-3-lavandulyl- 6-methoxybenzil (22)，和二十五個已知化合物，包含二個 pterocarpans (1, 2)、二個 chromones (3, 4)、一個triterpene (5)、一個benzoate (6)、九個 flavanones (7~10, 12~16)、二個 flavonols (17, 19)、一個 2-aryl benzofuran (20)、一個medicagol (23)、四個 isoflavones (24~27)、一個coumarin (28) 和一個chalcone (29) 類化合物。這些化合物是經由質譜及核磁共振光譜的分析而確認。
關鍵字
苦參根部並列摘要
The occurrence of alkaloids and flavonoids were reported previously in Sophora flavescens. We reinvestigated the constituents of S. flavescens which was collected from Hualien, Taiwan. A combination of several chromatographic techniques (silica gel, Sephadex LH-20 and HPLC) led to the isolation of four new compounds (including 5,7,2'4'-tetrahydroxy -5'-methoxy-8-lavandulylflavanone 11, 8-lavandulyl-kaempferol 18, 2-(2',4'-dihydroxy-5'-prenylphenyl)-5,6-methylenedioxybenzofuran 21 and 2,4,2’,4’-tetrahydroxy-3-lavandulyl-6-methoxybenzil 22) and twenty- five known compounds (including two pterocarpans, two chromones, one triterpene, one benzoate, nine flavanones, two flavonols, one 2-aryl benzofuran, four isoflavones one coumarin and one chalcone) from the MeOH extract of the roots of S. flavescens. Their structures were elucidated using mass and NMR spectral methods.
並列關鍵字
Sophora flavescens參考文獻
延伸閱讀
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- 李嶸泰、江怡蓁（2022）。Root Functional Traits and Biomechanical Properties of Four Endemic Fagaceae Species。臺灣林業科學，37(2)，145-156。https://www.airitilibrary.com/Article/Detail?DocID=10264469-202206-202210190014-202210190014-145-156
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