不同醯基鏈長之異植物神經醯胺的合成以應用於癌症治療的研究

Study on the Synthesis of the Isophytoceramide with Various Acyl Chain Length Used in Cancer Therapy

謝佩純(Pei-Chun Hsieh)

指導教授 ： 蔡祐輔

中原大學/理學院/化學研究所/碩士(2020年)

https://doi.org/10.6840/cycu202000497

摘要

近年來有些研究應用神經醯胺(ceramide)來探討抗癌的可能性。本論文意在從事神經醯胺的合成，以尋得治療癌症的藥物。以(D)-來蘇醣((D)-lyxose)為起始物建構出植物鞘鞍醇衍生物Lyx-6，並與以1,10-十烷二醇(1,10-decanediol)所建構出的異形結構碳鏈Dol-7 進行Grubbs’烯烴複分解反應得異植物鞘鞍醇Lyx-9，再與不同碳鏈長的飽和脂肪酸進行醯胺化反應得到神經醯胺(ceramide)：LF6-1, LF10-1, LF16-1。

關鍵字

異植物神經醯胺

並列摘要

In recent years, Ceramide has been standied as an anti cancer drug candidate . The purpose of this thesis is to engage in the synthesis of ceramides in order to find drugs to treat cancer. (D)-lyxose was used as the starting material to construct a plant sphingosine derivative Lyx-6 , and w ith 1,10-decanediol The heterostructure carbon chain Dol-7 constructed undergoes olefin metathesis reaction with Grubbs’ Catalyst to obtain
phytosphingosine Lyx-9 , and then undergoes amidation reaction with s aturated fatty acids to obtain ceramide, LF6-1 , LF10-1 , and LF16-1.

並列關鍵字

Isophytoceramide

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