In the time of Industrial Revolution 4.0, Vietnamese market are getting more and more ready for the rise of smart products. In fact, there are already many types of smart products in Vietnamese market. Autonomous vehicles (AVs) are not new products, but they are relatively new in Vietnam. Therefore, in the context of this research, we will explore the possibility of Vietnamese consumers accepting the use of autonomous vehicles. The study is developed with a goal to identify the main driving factors from Unified Theory of Acceptance, and Use of Technology (UTAUT2), with two additional factors of Data Privacy Concerns and Technology Anxiety, and the magnitude of the effects they have on the Intention to Use AVs in Vietnam. By examining previous literatures, causal factors are selected from UTAUT 2, and they are: Performance Expectancy, Effort Expectancy, Social Influence, Facilitating Conditions, Hedonic Motivation, Price Sensitivity, adding Data Privacy Concerns and Technology Anxiety. Quantitative research method is used with primary date collected from 400 respondents who are Vietnamese and/or living in Vietnam. The questionnaire contains 38 items which are extracted from the measurement scales provided by prior researchers. Multiple linear regression is used to quantify the effect of selected factors on Intention to Use AVs. By measuring the effects of Effort Expectancy, Performance Expectancy, Social Influence, Facilitating Conditions, Hedonic Motivation, Price Sensitivity, Data Privacy Concerns and Technology Anxiety on Intention to Use AVs, it is expected that this research can assist AV manufacturers to further understand their potential customers, and help strengthen the literature about customers Intention to Use in Vietnam. This will have positive effects, since the literatures about AVs in Vietnam are still limited in number.