低溫電漿改質竹炭與PEEK 表面對沉積HAp 的影響

Surface Modification of Bamboo Charcoal or PEEK by Low-temperature Plasma for HAp Deposition

李怡萱(Yi-Hsuan Lee)

指導教授 ： 陳克紹

大同大學/工程學院/材料工程學系所/碩士(2011年)

摘要

氫氧基磷灰石(Hydroxyapatite , HAp)為人體骨骼中含量較多的磷酸鈣鹽類結構，披覆於醫療植入物表面上，可以增進基材之生物適應性(biocompatibility)。許多塗佈HAp於材料表面的方式，其中浸泡模擬人體體液(simulated body fluid , SBF)之方式，可透過時間決定沉積的厚度、於常溫下進行可得到高純度的結晶和產物同性質等之特性。因此本實驗採用此方法將HAp成長於材料表面。聚醚醚酮(polyetheretherketone，PEEK)具生物惰性、耐磨損、耐熱、抗靜電和耐化學腐蝕等特性。另外，竹炭具多孔及輕之特性且密度低，與骨質相近。兩種基材的表面經適當的表面改質後，可望成為新的輕骨填補材料。但基材因為惰性材料不易沉積HAp，故本研究利用低溫電漿化學氣相沉積法沉積六甲基二矽胺烷 (Hexamethyldisilazan，HMDSZ)薄膜，使基材表面形成Si-CH3疏水性之官能基，再分別利用O2、Ar電漿活化有機矽膜表面其改善親疏水性，進而浸泡於SBF中。探討表面處理親疏水性變化對浸泡SBF時間沉積析出HAp的影響，結果發現PEEK與竹炭基材表面電漿沉積HMDSZ呈疏水性，分別約為98.2°和117°，而隨沉積HMDSZ時間越長，經浸泡於SBF後，水接觸角越小。且經O2、Ar電漿活化後之表面成親水性，而會隨浸泡SBF天數而下降。並由重量分析結果，PEEK原始重量約為146.5mg，經電漿改質後浸泡於SBF十天之重量變化，以電漿沉積HMDSZ處理及O2或Ar電漿活化後重量皆增加約10mg(0.1%)；而竹碳原始約為46.3mg，經HMDSZ沉積後重量約增加27.8mg(8%)經O2電漿活化後重量約可增加68.2mg(10%)、Ar電漿活化後重量約可增加44.5mg(9%)；由SEM表面形貌觀察，經電漿處理後之竹炭與PEEK表面浸泡於SBF後，發現有類似結晶顆粒的形貌出現，而由micro-IR或FTIR圖譜分析，經改質後之竹炭與PEEK基材表面有PO4和OH吸收峰出現，此為HAp主要的官能基。

關鍵字

聚醚醚酮 ； 竹炭 ； 氫氧基磷灰石 ； 電漿輔助化學沉積法 ； 模擬

並列摘要

Hydroxyapatite (HAp) is becoming increasingly popular as a passive material on grafts such as surgical implants in the orthopedic and dental fields. HAp has been extensively applied because of its superior biocompatibility and bioactivity. This study using dipped in the Simulated Body Fluid (SBF) solution investigate into the coating of the biomedical calcium phosphate on the polyetheretherketone (PEEK) and bamboo charcoal.
In this study, the plasma enhanced chemical vapor deposition (PECVD) of Hexamethyldisilazane (HMDSZ) was used to obtain a thin adhesive film on the surface of Polyether ether ketone (PEEK) and bamboo charcoal. The film was subsequently treated with O2 or Ar plasma, respectively. These processes provide for hydrophilic surface of PEEK and bamboo charcoal. Then PEEK and bamboo charcoal was dipped in the Simulated Body Fluid (SBF) solution at physiological condition with shaking on the constant temperature water bath (37℃、PH7.4) for 1~10 days. After the deposition of HAp on the PEEK and bamboo charcoal surface, it can provide useful functional group to improve biological compatibility.
PEEK and bamboo charcoal surface had hydrophobic layer through HMDSZ plasma deposition, then PEEK and bamboo charcoal surface had the Si-CH3 functional group then dipped in the SBF, for this reason the water contact angle decreased with time of HMDSZ plasma deposition. Nevertheless, after the O2 or Ar plasma treatment on PEEK and bamboo charcoal surface, for this reason the water contact angle decreased with time of dipped in the SBF. In addition, PEEK weight increased about 0.1% and bamboo charcoal weight increased about 9% after plasma treatment and immersed in SBF for 10 days.

並列關鍵字

SBF ； PEEK ； bamboo charcoal ； HAp ； PECVD

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