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  • 學位論文

強度調控放射治療中呼吸運動所產生的劑量差異

Motion-Induced Dose Artifact in Intensity Modulated Radiation Therapy

指導教授 : 趙敏
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摘要


呼吸運動是一個特別令人關注的複雜治療方式,主要是因為呼吸運動會造成腫瘤的體積以及腫瘤的形狀不準確,還有正常器官位置的位移,所以呼吸運動是一個很需要關注的問題。在患者體內,呼吸運動也會造成劑量的不確定。本篇研究主要就是探討因為呼吸運動的速度所引起的劑量差異以及這兩者之間的相互作用影響。 我們使用MLC Shaper 6.3將多葉式準直儀設計為靜態式和動態式多葉式準直儀這兩種型式,照野大小為10公分×10公分,並且分成5個照射階段以及5個移動的階段。我們製作了一個二維的移動假體來進行測量,並且在兩塊5公分厚的固態水假體之間放置柯達XV底片進行測量。而移動假體的振幅以及週期我們分別設為0.5公分、1公分、1.5公分、2公分以及2秒、3秒、4秒和5秒,所有測量出的結果將與靜止不動的底片來進行比較。從結果中可得知,在最大的位移以及最長的週期時間裡,他不僅有較長的半影區,就連有些照射的區域也都會被轉移掉。因此,呼吸運動會導致不均勻的劑量,也會導致照射的時候,有位移的現象出現。當載具移動速度越快的時候,位移的現象以及劑量差異的情形就越大。

並列摘要


Tumor motion is a particular concern for a complex treatment modality. Due to motion, it give an inaccurate representation of the shape, and position of normal organs and target volumes. Tumor motion induce undetermined dose artifact in the patient body. This study investigated motion velocity caused dose artifact due to interplay effect. We created step-and-shoot and Sliding window field with 10×10 cm2 in MLC Shaper 6.3.There are 5 irradiated segments and 5 moving segments. We set up a measurement on a moving platform, include two slab 5cm-thickness solid water phantoms and a Kodak XV film put in two slabs. The platform was moving with a displacement(0.5 cm, 1 cm, 1.5 cm, 2 cm) and a period(2 sec, 3 sec, 4 sec, 5 sec) respectively. All of the results are compared with static film. With large displacement and longer period, not only the penumbra has longer, the irradiated segment was shifted. The motion cause the non-homogeneity dose, but also made the irradiated segment a shift. The dose deviation and segment shift is higher as the higher velocity of the motion.

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