- 期刊
Pentoxifylline在慢性腎臟病治療的角色
The Role of Pentoxifylline in the Management of Chronic Kidney Disease
摘要
針對pentoxifylline對慢性腎臟病治療的角色，近十年來的臨床研究證明相較於單獨使用腎素－血管收縮素－醛固酮系統抑制劑（renin-angiotensin-aldosterone system inhibitor, RAAS inhibitor），與pentoxifylline合併使用不僅能改善糖尿病慢性腎病合併有蛋白尿的病人其血糖控制與蛋白尿惡化，更能延緩其腎功能下降；透過資料庫分析，也證明在第5期慢性腎臟病病人不管是單獨使用pentoxifylline或是與RAAS inhibitor合併使用，都能延後接受腎臟替代療法的時間。然而，pentoxifylline對於非糖尿病之慢性腎臟病或是慢性腎臟病的貧血的療效仍未明確。
並列摘要
About the role of pentoxifylline in the treatment of chronic kidney disease (CKD), recent clinical evidence demonstrated that compared with renin-angiotensin-aldosterone system inhibitor (RAAS inhibitor) monotherapy, RAAS inhibitor plus pentoxifylline could further improve glucose control, reduce proteinuria, and even delay deterioration of glomerular filtration rate (GFR) in patients with diabetic CKD and proteinuria. Moreover, shown by nationwide cohort studies, either pentoxifylline monotherapy or RAAS inhibitor plus pentoxifylline could reduce the risk of receiving long-term renal replacement therapy in patients with stage 5 CKD. However, whether pentoxifylline has therapeutic effects over non-diabetic CKD or CKD-related anemia is still not well proved.