The article is about a successful clinical case of using mechanical ventilation with protective lung strategy and extracorporeal membrane oxygenation. In the case, the patient was diagnosed with acute cardiac tamponade. Such a massive amount of hemorrhage lead to cardiogenic shock and cardiogenic pulmonary edema caused by cardiac vascular rupture after cardiac catheterization of acute myocardial infarction. The need of fluid challenge due to massive amount of hemorrhage and thoracotomy hemostasis caused respiratory failure. Lung protection strategy is proved to be a widely used and safe way to improve oxygenation, but it used mostly in acute respiratory distress syndrome in the past. To the use of extracorporeal membrane oxygenation with severe hypoxemia in non-respiratory distress syndrome has no certain related recommendations. Therefore, I would like to explore the use of lung protection strategy mechanical ventilation and extracorporeal membrane oxygenation therapy to severe hypoxemia patients with non-respiratory distress syndrome and make further discussion of improvement of oxygenation trough this case.