Asthma is a controllable but refractory heterogeneous chronic disease. During asthma attacks, airway stenosis will worsen due to the inflammation and hyperplasia of airway smooth muscle. The expiratory flow will be blocked, causing lungs to be overinflated with ventilation and perfusion mismatch. If airway obstruction cannot be solved immediately, it will increase work of breath, accessory muscles of respiration used and lower the gas exchanged, leading to respiratory muscle fatigue and respiratory failure. This case is about a 69-year-old woman who has a history of asthma, was being intubated with mechanical ventilator used due to the acute asthma attack caused by pneumonia, resulting in long-term bed-ridden, activity tolerance inhibited and difficulty weaning from mechanical ventilation. She is being weaned from a mechanical ventilator through asthma control, antibiotic treatment and pulmonary rehabilitation, which can be considered as a perfect yet successful clinical experience.