In recent years, environmental issues have been fermented all over the world. Water-based ink has been used for rotogravure and flexography one after another in the printing business while solvent-based ink still for screen printing. How to use water-based ink for screen printing and efficiently retard the exhaust of VOCs (volatile organic compounds) becomes a real challenge for preserving the environment in the industry. This article mainly discusses the adaptability of water-based screen printing ink.