Journal of International Dental and Medical Research
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Ectodermal Dysplasia Group-Turkey,正常發行
選擇卷期
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Temporomandibular disorders (TMDs) is a collective term that embracing a number of clinical problems that involve the masticatory muscles, Temporomandibular Joint (TMJs), and the associated structures. It characterized by facial pain in the area of TMJ and muscle of mastication, restriction and sound during mandibular movement. Recently physical therapy such as Low Level Laser Therapy (LLLT) is used as one of the treatment modalities and it is believed to promote wound healing, tissue repair and induce analgesia. Convenience sampling was used which consist of 22 volunteered patients, 14 were treated with conventional treatment and 8 were treated with combination of LLLT and conventional therapy. Laser machine used was Waterlase/Biolase © 2007 with irradiation 0.5 W- 30 Hz daily for three consecutive days, then once a week review treatment for two weeks. The space between laser beam and skin is 3 cm, applied as small circles for 2-3 minutes. Pain intensity before and after the treatment was recorded by using numerical rating scale (NRS). Statistical data analysis was conducted using SPSS software. Wilcoxon-sign ranked-test and Mann-Whitney U test were used. Pain intensity was reduced significantly in patients whom treated by combination of LLLT and conventional therapy. (p＜0.05). Pain intensity after treatment for female were higher (M=1.20, SD=1.10) than for male (M=0.00, SD=0.00). Younger patients have higher pain intensity than older patients. LLLT is effective to be used as adjunct to the current conventional treatment in relieving pain in TMDs.
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Ginger has an active compound of phenol, flavonoids, terpenoids and essential oils that can inhibit microbial growth. Streptococcus mutans bacteria play an important role in the development of dental caries. To know the Antibacterial Effectiveness Analysis of Red Ginger Extract (Zingiber Officinale Var. Rubrum) Compared to White Ginger Extract (Zingiber Officinale Var. Amarum) In Mouth Cavity Bacterial Streptococcus Mutans (In-Vitro). Type of research used is laboratory experimental. The sample is a red Ginger extract (Zingiber officinale var. Rubrum) and white ginger extract (Zingiber officinale var. Amarum) and Bacteria used areStreptococcus mutans using the inhibitory test method. The highest average value of the highest group is shown in red ginger extract 60% of 15.90 mm, 40% by 14.73 mm and 20% by 12.70 mm. For White Ginger extract 60% by 11.90 mm, 40% by 11.15 mm, and 20% by 10.08 mm. Based on the normality test, Mann-Whitney test and T-test obtained p value ＜0.05 which means there is significant difference between inhibition between treatment group and overall measurement. Red Ginger Extract(Zingiber officinale var. Rubrum) and White Ginger Extract (Zingiber officinale var. Amarum) has an antibacterial effect onStreptococcus mutans. Red ginger extract at concentration of 60% has greater antibacterial effect inhibiting Streptococcus mutans compared to white ginger extract. Based on the results of the study the higher concentration of red ginger extract and white ginger the greater the inhibitory power diameter against Streptococcus mutans.
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Abstract Propolis is one of bee's product which harboring many biological compounds including flavonoid. Considering all biological aspects in oral medicament development, both benefit and biocompatibility issues must be confirmed. Enterococcus faecalis and Porphyromonas gingivalis are known to be the critical oral pathogenic bacteria which are responsible for endodontic failure and periodontal diseases respectively. The purpose of this study was to investigate the effect of ethanolic propolis compound from Apis Trigona towards bacterial growth and cytotoxicity. Propolis Apis Trigona was taken from local apiary in Nglipar subdistrict of Yogyakarta, Indonesia and was extracted using maceration procedure. Enterococcus faecalis and Porphyromonas gingivalis were used for bacterial growth evaluation, while fibroblast cells were used for cytotoxic analysis. One way Anova, Kruskal Wallis and Pearson tests were were performed for statistical analysis. All treatments were performed in triplicate experimental design. The variances analysis showed p=0.000 and p=0.009 for the effect of ethanolic propolis which indicated potential results, while Pearson correlation coefficient showed the score -0.673 which indicated strong negative correlation. Taken together, these results suggested that the higher bacterial inhibitory capacity, the lower cells viability on the contrary. Further investigations are required for gaining the optimum benefit from propolis Apis Trigona in a higher biocompatibility.
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Down Syndrome (DS), also known as Trisomy 21 is one of the most common genetic disorders in which there is an extra copy of chromosome 21. DS occurs in about 1 to 650-1000 live births and it can be caused by three types of chromosomal abnormalities: Non-disjunction, Translocation and Mosaicism. The aim of this study is to determine the percentage for each type of DS among patients who came to Rumah Sakit Gigi dan Mulut Fakultas Kedokteran Gigi Universitas Padjadjaran (RSGM FKG UNPAD). This was a descriptive cross-sectional study. The sample for this research was 75 individuals suspected of DS who have given their blood for karyotype testing, however 5 samples were later excluded as the karyotype results either showed other chromosomal abbreviation than that of trisomy 21 or were normal or the blood sample failed to be cultured. The results of this study showed that the valid total of 70 samples, 67 samples (95.71%) were Non-disjunction DS and 3 samples (4.29%) with Mosaicism. The overall male:female ratio of DS samples was found to be 1.92:1. In conclusion, Non-disjunction was diagnosed in the majority of the samples similar with other cytogenetic studies on DS worldwide. However, Translocation DS was not reported and the percentage of Mosaic DS was slightly higher than other researches.
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Gingiva is emerging as a source of Mesenchymal Stem Cells. Gingival Mesenchymal Stem Cell has been isolated and characterized from the gingival connective tissue of wistar rat (Rattus Novergicus). Gingival Mesenchymal Stem Cell sources are rich, attainable and easy to isolate through minimal invasive procedure. Gingival Mesenchymal Stem Cells are ideal to accelerate bone regeneration. The aim of this study was to analyze Gingival Mesenchymal Stem Cells from Wistar Rats' gingiva (Rattus Novergicus) isolation and characterization by CD34, CD44, CD73, CD90, CD105 expression. This study was descriptive observational with simple random sampling method. Gingival Mesenchymal Stem Cells were isolated from healthy, 200 gram, 1 month year old, male rat's (Rattus Novergicus) lower gingival tissue through gingivectomy procedure (n=4). Gingiva were minced into small fragments then cultured in 2 weeks. The culture was passaged every 3-5 days after cultured and plated. The isolated Gingival Mesenchymal Stem Cells in passage 5 were characterized by CD34, CD44, CD73, CD90, CD105 using Immunocytochemistry and flowcytometry examination. Gingival Mesenchymal Stem Cells strongly expressed CD44+, CD73+, CD90+, CD105+ but did not express CD45- and CD34-. Gingival Mesenchymal Stem Cells' morphology was fibroblast-like, spindle-shaped, colony-forming abilities, and stick to the culture plate. Gingiva is potential Stem Cell source. Gingival Mesenchymal Stem Cells has multipotency ability with proliferation and mesenchymal stem cells characteristic advantageous for tissue engineering and regenerative therapy.
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Aggregatibacter actinomycetemcomitans (Aa) is a potentially periodontal bacteria causing periodontal tissue destruction, which may not be cleaned at the time of scaling and root planing. Piper betle Linn which has long been used as a traditional medicine in Indonesia to cure various diseases in the mouth, potentially also as an adjunctive therapy in periodontitis. The objective of the research was to investigate the effect of betel leaf fraction on the growth of Aa bacteria. Materials and methods: Fresh betel leaf extraction with water, n-hexane, ethyl acetate and ethanol and 95% ethanol extract (EtOH) showed the highest inhibitory effect against Aa bacteria. 95% EtOH fractionated yielded 6 active fractions, then tested its antibacterial activity against Aa. Results: Fractionation of EtOH 95% yielded 6 active fractions comprising FrEtOH 30%, 50%, 100%, 10%, 20% and FW 100%. The test results of the 95% EtOH fraction showed 4 fractions that have inhibitory power against Aa bacteria. Conclusion: The 100% EtOH fraction shows the highest inhibitory effect against Aa bacteria.
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Gummy smile represent excessive gingival display in the maxilla upon smiling. This case report aims to explain the alternative surgical method to treat gummy smile by positioning the vestibule more coronally. This method advantageous because the surgical is performed without reduction of vertical dimension of labial mucosa. A 40-year-old female presenting the esthetic problem of excessive gingival display when smiling. The surgical is performed on the vestibule of the left to right second premolar in order to positioning the vestibule more coronally. One month after surgery, excessive gingival display has been significantly reduced.
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The digital era has led to young people being exposed to the Internet at an early age, increasing the risk of problems related to emotional development. Consequently, Internet addiction can be found in 40% of adolescents in Asia. Because adolescence is a critical phase in a person's emotional development, this study explores the impact of Internet addiction on adolescents. Semistructured interviews were conducted with 19 adolescents who were purposely recruited through Internet café settings in Jakarta (n = 19). Fifteen males and four females participated in this study. The main topics were participants' characteristics, the extent and consequences of Internet use, and their knowledge about Internet addiction. Interviews were audio-recorded, transcribed, and analyzed by the author using thematic analysis. The results showed distinct characteristics and the extent of Internet use between male and female adolescents. Considering today’s lifestyle, adolescents can be considered vulnerable to Internet addiction.
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Hemodialysis treatment is a replacement therapy renal function. Hemodialysis therapy with reuse system causes a risk of bacterial infection. In addition, routine vascular access by hemodialysis patients also factors of bacterial contamination which can increase the comorbidity and mortality rates of patients. This research aims to obtain biocompatibility and antibacterial properties by adding concentration chitosan in three variations. The functional group test showed the presence of a bond between PU-CA-PES-CS at a certain wavelength. SEM test proved that the pores produced on dialyzer membrane are still within the size range for the hemodialysis application at 0.001-0.1 μm. Hemolysis test results showed that the percentage of hemolysis in Sample A, Sample B, Sample C, and Sample D were 4.18%, 3.34%, 2.30% and 1.67% respectively. The percentage of hemolysis at less 5% is safe for contact with blood. Antibacterial test results revealed that PES-PU-CA membrane samples coated with chitosan variation are antibacterial. It can be seen from the formation of clear zone around the sample disc with diameter of 6,946-11,086 mm. PES-PU-CA dialyzer membrane coated with chitosan is a safe composite and potentially applicable as an antibacterial dialyzer membrane based on functional group test, antibacterial test, hemolysis assay, SEM, and cytotoxicity test.
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The incidence of postcholecystectomy syndrome (PCS) at Cipto Mangunkusumo Hospital, Indonesia, was previously found to be 54.29% (2012), which was higher than those reported in other countries. This research was undertaken to identify the risk factors for PCS in developing countries with limited resources and facilities. This was a cross-sectional study of all patients who underwent cholecystectomy in our hospital during 2015. The variables included sex, body mass index, preoperative symptom duration, preoperative flatulence, level of education, preoperative symptoms, preoperative awareness, and preoperative ultrasound. All the data were analyzed through bivariate and multivariate analyses. In total, 112 patients who underwent laparoscopic cholecystectomy were followed. We found the incidence of PCS to be 45.5%. Multivariate logistic regression analysis showed that preoperative flatulence (P ≤ 0.001, OR = 17.152), nonspecific preoperative symptoms (P = 0.012, OR = 3.984), and patients’ poor preoperative awareness of PCS (P = 0.003, OR = 5.907) were independent predictive factors for PCS. Statistically significant correlation between patients' awareness and preoperative education (P ≤ 0.001, OR = 69.00) was found. We concluded that preoperative flatulence, nonspecific preoperative symptoms, and poor preoperative awareness increased the incidence of PCS. Besides abdominal ultrasound, other examinations, such as upper GI endoscopy, for nonspecific preoperative symptoms that do not meet the Rome III criteria are recommended to rule out the diagnosis and avoid unnecessary surgeries. Adequate preoperative information and education may reduce the incidence of PCS.