幼兒之番木鼈鹼(Strychnine)中毒之一例

A case of strychnine poisoning in a 13-month-old boy is presented. The patient has been suffering from diarrhea for about a month after weaning. For treating Ids abdominal distention his mother got some blackish herb pills of unknown content, which weighed 0.25 gin each. After taking two of the pills the patient looked somewhat uneasy; 10 hours later again two pills were given and three hours later the patient showed twitching; then the mother gave him three more pills and half an hour later tonic convulsion, opisotonus, cyanosis, consciousness disturbance and clonic twitching occurred to the patient. After the administration of 0.1gm of seconal rectally and 25mg of wintermin intramuscularly at our Emergency Service, the symptoms gradually calmed down and the patient completely recovered the following day. By using unidimentional ascending paper chromatography and qualitative analysis it was confirmed that the pills contained strychnine. The chemistry, pharmacology, and treatment of intoxication of strychnine are reviewed and the methods used for chemical analysis of strychnine in this case are also described.

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