Title

1,4-二氫-4-芳基-3,5-吡啶二羧酸酯的合成及表徵

Translated Titles

Synthesis and Characterization of 4-Aryl-1,4-dihydropyridine-3,5-dicarboxylates

Authors

伍小雲(Xiao-Yun Wu);胡艾希(Ai-Xi Hu);謝豔麗(Yan-Li Xie)

Key Words

1,4-二氫-4-芳基-3,5-吡啶二羧酸酯 ; 合成 ; 表徵 ; 相轉移催化 ; 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylate ; synthesis ; characterization ; phase transfer catalysis

PublicationName

有機化學

Volume or Term/Year and Month of Publication

26卷1期(2006 / 01 / 01)

Page #

93 - 98

Content Language

簡體中文

Chinese Abstract

基於二氫吡啶化合物的構效關係,設計了一系列l,4-二氫-4-芳基-3,5-吡啶二羧酸酯新化合物。含有易於水解基團的1,4-二氫-4-芳基-3,5-吡啶二羧酸酯類化合物在鹼性條件下水解合成了重要中間體1,4-二氫-4-芳基-3,5-吡啶二羧酸單酯,收率93%~99.8%。該二羧酸單酯與α-溴代芳基乙酮在相轉移劑催化下反應合成目標化合物,收率74%~99%。中間體和目標化合物經1H NMR,13C NMR,IR,MS和元素分析等確證。

English Abstract

New 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates were designed and synthesized by the reaction of 1,4-dihydro-3,5-pyridinedicarboxylic monoesters with α-bromoarylketones by phase transfer catalysis in 74%~99%. The 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylic monoesters were prepared by the hydrolysis of 4-aryl-5-(2'-cyanoethyl)-1,4-dihydro-3,5-pyridine dicarboxylates with yields of 93%~99.8%. The intermediates and target compounds were characterized by 1H NMR, 13C NMR, IR, MS spectra and elemental analyses.

Topic Category 基礎與應用科學 > 化學