Title

原發性高血壓與腎實質性高血壓患者腎上腺髓質素前體N端20肽水平的臨床觀察

Translated Titles

Elucidation of the Changes of Proadrenomedullin N-terminal 20 Peptide Level in Hypertension Patients with EH and RH

Authors

張昭馥(Zhao-Fu Zhang);石湘芸(Xiang-Yun Shi);費宇行(Yu-Xing Fei);唐朝樞

Key Words

腎上腺髓質素前體N端20肽 ; 舒血管肽 ; 高血壓 ; Proadrenomedullin N-terminal 20 peptide (PAMP) ; Vasodilator peptide ; Hypertension

PublicationName

北京醫學

Volume or Term/Year and Month of Publication

24卷4期(2002 / 08 / 10)

Page #

222 - 224

Content Language

簡體中文

Chinese Abstract

目的 觀察原發性高血壓(EH)與腎實質性高血壓(RH)患者腎上腺髓質素前體N端20肽(PAMP)水平的變化,探討PAMP的降壓機制。方法 用放免法測定EH與RH患者的血漿PAMP,用高壓液相(HPLC)法測定去甲腎上腺素(NE)、腎上腺素(E)的水平。結果 EH及RH患者PAMP、NE、E均較正常人明顯增高,PAMP、MAP與NE、E有明顯相關性。結論 EH及RH患者PAMP增高可能是機體維持自穩態的一種保護性代償機制,EH與RH代償程度有所不同。PAMP降壓作用與拮抗NE、E有關。

English Abstract

Objective To assess the changes of proadrenomedullin N-terminal 20 peptide (PAMP) in patients with essential hypetension (EH) and renal hypertension (RH) and explore the mechanism of PAMP in lowing blood pressure. Methods Plasma concentrations of PAMP、nor-adrenalin (NE) and adrenalin (E) in EH and RH patients were measured by radio-immunoassay(RIA) and HPLC and their associations were calculated. Results Plasma concentrations of PAMP、NE and E in patients with EH and RH were significantly higher than those of normal people. PAMP and the mean arterial pressure (MAP) had significant correlation with NE and E. Conclusions PAMP is a vasodilator peptide. The increase of plasma PAMP may be the self-compensatory mechanism by which the body maintains homeostasis. There was a difference in compensatory level between the patients with EH and RH. The action of PAMP in lowing blood pressure is due to the inhibition of NE and E.

Topic Category 醫藥衛生 > 醫藥衛生綜合