CYP3A5*1 is an Inhibitory Factor for Lung Cancer in Taiwanese

Translated Titles



葉坤土(Kun-Tu Yeh);陳瑞彰(Jui-Chang Chen);陳志玫(Chih-Mei Chen);王毓芬(Yu-Fen Wang);李黛苹(Tai-Ping Lee);張建國(Jan-Gowth Chang)

Key Words

CYP3A5 ; 多形性變 ; 肺癌 ; CYP3A5 ; polymorphism ; lung cancer


The Kaohsiung Journal of Medical Sciences

Volume or Term/Year and Month of Publication

19卷5期(2003 / 05 / 01)

Page #

201 - 207

Content Language


Chinese Abstract


English Abstract

The expression of the cytochrome P450 CYP3A5 enzymes shows a wide variation across the general population and ethnic groups. This wide disparity implies interracial differences in drug clearance and susceptibility to diseases such as cancer. CYP3A5 polymorphisms were rapidly determined using polymerase chain reaction-restriction fragment length polymorphism analysis in 113 Taiwanese patients with hepatoma, 70 with cervical cancer, 92 with breast cancer, 82 with oral cancer, 90 with thyroid cancer ,133 with lung cancer ,and 270 healthy controls. The allelic frequencies of CYP3A5*1 were 25%in hepatoma patients, 3%in cervical cancer patients, 31%in breast cancer patients,22% in oral cancer patients, and 27% in healthy subjects .Lung cancer patients had a significantly lower frequency (20%)of CYP3A5*1 expression than healthy controls(p=0.028,odds ratio=1.49, 95% confidence interval=1.04-2.13),but there was no statistically significant difference between healthy controls and other cancers. We suggest that CYP3A5*1 may play an important role in individual predisposition to lung cancer in Taiwan.

Topic Category 醫藥衛生 > 醫藥衛生綜合