Effects of Total Coronary Artery Occlusion on Vascular Endothelial Growth Factor and Transforming Growth Factor β

血管內皮生長因子(VEGF)及轉形生長因子(TGF-βl)在有完全冠狀動脈阻塞病人身上的角色

林宗憲(Tsung-Hsien Lin) ； 顏學偉(Hsueh-Wei Yen) ； 蘇河名(Ho-Ming Su) ； 簡婉婷(Wan-Ting Chien) ； 盧怡旭(Ye-Hsu Lu) ； 溫文才(Wen-Chol Voon) ； 賴文德(Wen-Ter Lai) ； 許勝雄(Sheng-Hsiung Sheu)

《The Kaohsiung Journal of Medical Sciences》 21卷10期 (2005/10) Pp. 460-465

摘要

血管內皮生長因子(VEGF)及轉形生長因子(TGF-β)對於血管新生扮演重要的角色。因為少有研究探討局部生長因子濃度與血管新生的關係。因此我們探討是否心臟內（冠狀動脈竇，coronary sinus）及右心房(right atrium)內血管內皮生長因子及轉形生長因子濃度與病人有否完全冠狀動脈阻塞間有相關。51位接受心導管病人評估進行此研究。其中47病人接受心導管前以6F Goodale-Lubin導管成功收集冠狀動脈竇及右心房內血液以供分析。在47位病人中，32位病人至少有一條冠狀動脈疾病。其中7位至少有一條冠狀動脈完全阻塞。32位病人中我們發現血管內皮生長因子在冠狀動脈竇內明顯比右心房內高(31.5±2.7 vs 27.1±1.8pg/ml，p=0.005)。冠狀動脈竇內血管內皮生長因子在有完全冠狀動脈阻塞病人身上明顯比無完全冠狀動脈阻塞病人高(38.9±8.0 vs 29.5±2.6pg/ml，p=0.037)。TGF-β1濃度在兩組間並無達到統計學上的差異。有完全冠狀動脈阻塞病人身上冠狀動脈竇內血管內皮生長因子濃度明顯比無完全冠狀動脈阻塞病人高，如此顯示局部血管內皮生長因子可能在血管新生上伴演一部份角色。

關鍵字

血管內皮生長因子 ； 轉形生長因子 ； 冠狀動脈疾病 ； 完全阻塞

並列摘要

Vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β1) play an important role in angiogenesis. We wanted to determine if concentrations of growth factors in the coronary sinus (CS) and right atrium (RA) are higher in coronary artery disease patients with total occlusions than in those with partial occlusions. Fifty-one patients scheduled for coronary artery angiography were evaluated for possible recruitment. A 6F Goodale-Lubin catheter was used to collect blood from the CS and RA. Data for all but four patients were gathered successfully, leaving 47 study patients. The reviewer was blinded to growth factor data when interpreting coronary angiographic findings. Of the 47 enrolled patients, 32 had at least one diseased vessel, seven of whom had at least one major total epicardial coronary occlusion. In all 32 patients, the concentrations of VEGF in the CS were higher than those in the RA (31.5±2.7 vs 27.1±1.8pg/mL; p=0.005). Patients with total occlusions had higher VEGF concentrations in the CS than those with non-total occlusions (38.9±8.0 vs 29.5±2.6pg/mL; p=0.037). The differences in TGF-β1 in the two groups were not statistically significant. The higher CS VEGF concentrations in patients with total occlusion indicate that VEGF may play a part in the development of angiogenesis.

並列關鍵字

vascular endothelial growth factor ； transforming growth factor ； coronary artery disease ； total occlusion