Expression of Protein Kinase C Alpha in Biopsies and Surgical Specimens of Human Hepatocellular Carcinoma


Jen-Hsiang Tsai;Min-Ting Tsai;Wei-Wen Su;Yao-Li Chen;Trang-Tiau Wu;Yih-Shou Hsieh;Chih-Yang Huang;Kun-Tu Yeh;Jer-Yuh Liu

Key Words

anesthetic ; hepatocellular carcinoma ; protein kinase C alpha


The Chinese Journal of Physiology

Volume or Term/Year and Month of Publication

48卷3期(2005 / 09 / 30)

Page #

139 - 143

Content Language


English Abstract

Variations in the activity of protein kinase C (PKC) have been observed in different types of tumors. Although these inconsistent findings may be attributed to the alterations of individual PKC isoforms, the effects of general anesthetic may not be neglected. In this study, biopsies and surgical specimens were obtained from patients with HCC, and the levels of PKCα were analyzed by immunohistochemistry. PKCα expression in biopsies was mainly revealed on the cell membrane of hepatocytes whereas that in the surgical specimens was in the cytosol and on the membrane. In both types of specimens, the PKCα level in HCC was significantly higher than that in the adjacent nontumorous tissue. Moreover, the level of PKCα in biopsies was significantly higher than that in surgical specimens of the corresponding tissue type. These findings suggested that general anesthetics may significantly affect the expression of PKCα, and the effects of anesthetics should not be neglected in observations which were made only based on surgical specimens.

Topic Category 醫藥衛生 > 基礎醫學
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Times Cited
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  2. Yen, Shiow-Kang,Tsai, Min-Ting,Su, Wei-Wen,Liu, Jer-Yuh,Lin, Chien-Chung,Lai, Tung-Yuan,Hwang, Jin-Ming,Huang, Chih-Yang,Hsu, Hsi-Hsien,Chen, Li-Mien(2010).Protein Kinase C Alpha Location and the Expression of Phospho-MEK and MDR1 in Hepatitis Virus-Related Hepatocellular Carcinoma Biopsies.Chinese Journal of Physiology,53(2),112-118.
  3. Ying, Tsung-Ho,Wu, Trang-Tiau,Tsai, Min-Ting,Tsai, Jen-Hsiang,Su, Wei-Wen,Liu, Jer-Yuh,Hsieh, Yih-Shou(2008).Immunochemical Localization of Protein Kinase Cα in the Biopsies of Human Hepatocellular Carcinoma.Chinese Journal of Physiology,51(5),269-274.
  4. Yung, Jai-Nien,Yue, Chia-Herng,Tzang, Bor-Show,Shiu, Jiuan-Jen,Liu, Jer-Yuh,Hwang, Jin-Ming,Huang, Wen-Hung,Chiu, Yung-Wei(2012).Expression of Protein Kinase C α and the MZF-1 and Elk-1 Transcription Factors in Human Breast Cancer Cells.中國生理學雜誌,55(1),31-36.