Immunochemical Localization of Protein Kinase Cα in the Biopsies of Human Hepatocellular Carcinoma


Tsung-Ho Ying;Jen-Hsiang Tsai;Trang-Tiau Wu;Min-Ting Tsai;Wei-Wen Su;Yih-Shou Hsieh;Jer-Yuh Liu

Key Words

hepatitis C virus ; hepatocellular carcinoma ; protein kinase C alpha


The Chinese Journal of Physiology

Volume or Term/Year and Month of Publication

51卷5期(2008 / 10 / 01)

Page #

269 - 274

Content Language


English Abstract

The purpose of this study was to elucidate the protein kinase C (PKC) α distribution in human hepatocellular carcinoma (HCC). The histoimmunopathologic technique was used to determine the localization and expression of PKCα in HCC biopsies. The HCC tissues were classified as cytosolic type (PKCα deposited in the cytoplasm in >50% of cells) and membranous type for the remaining ones. There was a significant association of the membranous type with non-hepatitis C virus (HCV) infected patients. Moreover, the expression of PKCα in this type was significantly higher in HCC cells than that in the adjacent non-tumor liver cells. The result indicated that PKCα may play an important role in carcinogenesis of HCC patients with HBV infection and/or non-HCV infection.

Topic Category 醫藥衛生 > 基礎醫學
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Times Cited
  1. Yen, Shiow-Kang,Tsai, Min-Ting,Su, Wei-Wen,Liu, Jer-Yuh,Lin, Chien-Chung,Lai, Tung-Yuan,Hwang, Jin-Ming,Huang, Chih-Yang,Hsu, Hsi-Hsien,Chen, Li-Mien(2010).Protein Kinase C Alpha Location and the Expression of Phospho-MEK and MDR1 in Hepatitis Virus-Related Hepatocellular Carcinoma Biopsies.Chinese Journal of Physiology,53(2),112-118.