Effects of Short-Term Dehydroepiandrosterone Supplementation on Body Composition in Young Athletes




Sergej M. Ostojic;Julio Calleja;Morteza Jourkesh

Key Words

testosterone ; body fat ; muscle mass ; estradiol


The Chinese Journal of Physiology

Volume or Term/Year and Month of Publication

53卷1期(2010 / 02 / 28)

Page #

19 - 25

Content Language


English Abstract

Dehydroepiandrosterone (DHEA) is often promoted as a slimming and weight/fat loss agent and ingestion of DHEA may have hypolipidemic and anti-obesity properties. The main aim of this studs vas to examine the effects of acute DHEA intake on both composition and serum steroid hormones in young athletes. Twenty young (19 to 22 years) male soccer players were allocated into to randomly assigned trials in double-blind design by ingesting 100-mg daily oral DHEA or as placebo (PLA) for 28 days. Body mass vas not affected by 4 weeks of DIIEA supplementation (P>0.05). No significant changes in body mass index (BMI), waist-to-hip ratio (WHR) and body fat or total muscle mass for the to groups were detected at the end of the trial (P>0.05). There vas no within-or between-group difference in arm fat index (AFI) and corrected mid-upper-arm muscle area (cAMA) (P>0.05). Treatment with DHEA resulted in a significant increase of total testosterone, estradiol and DIIEA-S levels in treated subjects versus the placebo group (P<0.05). Results of this study suggest that DHEA supplementation has no beneficial effects on body composition in young competitive athletes.

Topic Category 醫藥衛生 > 基礎醫學
  1. Ho, C. T.,Su, C. L.,Chen, M. T.,Liou, Y. F.,Lee, S. D.,Chien, K. Y.,Kuo, C. H.(2008).Aging effects on glycemic control and inflammation for politicians in Taiwan.Chinese J. Physiol.,51,402-407.
  2. Hsu, T. H.,Liu, Y. F.,Lee, S. D.,Chen, S. M.,Lee, J. P.,Fang, C. L.,Liu, T. C.,Kuo, C. H.(2008).Suppression of age-dependent increase in insulinemia in early middle-aged females with exercise habit.Chinese J. Physiol,51,263-268.
  3. Baulieu, E. E.,Thomas, G.,Legrain, S.,Lahlou, N.,Roger, M.,Debuire, B.,Faucounau, V.,Girard, L.,Hervy, M. P.,Latour, F.,Leaud, M. C.,Mokrane, A.,Pitti-Ferrandi, H.,Trivalle, C.,de Lacharriere, O.,Nouveau, S.,Rakoto-Arison, B.,Souberbielle, J. C.,Raison, J.,Le Bouc, Y.,Raynaud, A.,Girerd, X.,Forette, F.(2000).Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.Proc. Natl. Acad. Sci. USA.,97,4279-4284.
  4. Bernton, E.,Hoover, D.,Fein, H.,Galloway, R.,Popp, K.(1995).Adaptation to chronic stress in military trainees: adrenal androgens, testosterone, glucocorticoids, IGF-1 and immune function.Ann. N. Y. Acad. Sci.,774,217-231.
  5. Bowers, L. D.(1999).Oral dehydroepiandrosterone supplementation can increase the testosterone/epitestosterone ratio.Clin. Chem.,45,295-297.
  6. Brown, G. A.,Vukovich, M. D.,Sharp, R. L.,Reifenrath, T. A.,Parsons, K. A.,King, D. S.(1999).Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men.J. Appl. Physiol.,87,2274-283.
  7. Cleary, M. P.(1991).The antiobesity effect of dehydroepiandrosterone in rats.Proc. Soc. Exp. Biol. Med.,196,8-16.
  8. Ebeling, P.,Koivisto, V. A.(1994).Physiological importance of dehydroepiandrosterone.Lancet,343,1479-1481.
  9. Eichner, E. R.(1997).Ergogenic aids: what athletes are using-and why.Phys. Sportsmed,25,70-79.
  10. Gibson, R. S.(1993).Nutritional Assessment: A Laboratory Manual.Oxford:OUP.
  11. Hernández-Morante, J. J.,Pérez-de-Heredia, F.,Luján, J. A.,Zamora, S.,Garaulet, M.(2008).Role of DHEA-S on body fat distribution: gender- and depot-specific stimulation of adipose tissue lipolysis.Steroids,73,209-215.
  12. Hespel, P.,Maughan, R. J.,Greenhaff, P. L.(2006).Dietary supplements for football.J. Sports Sci.,24,749-761.
  13. Hoff, J.,Helgerud, J.(2004).Endurance and strength training for soccer players: physiological considerations.Sports Med.,34,165-180.
  14. Jackson, A.S,Pollock, M. L.(1978).Generalized equations for predicting body density of men.Br. J. Nutr.,40,497-504.
  15. Kahn, A. J.,Halloran, B.,Wolkowitz, O.,Brizendine, L.(2002).Dehydroepiandrosterone supplementation and bone turnover in middle-aged to elderly men.J. Clin. Endocrinol. Metab.,87,1544-1549.
  16. Kroboth, P. D.,Salek, F. S.,Pittenger, A. L.,Fabian, T. J.,Frye, R. F.(1999).DHEA and DHEA-S: a review.J. Clin. Pharmacol.,39,327-348.
  17. Martin, A. D.,Spenst, L. T.,Drinkwater, D. T.,Clarys, J. P.(1990).Anthropometric estimation of muscle mass in man.Med. Sci. Sports Exerc.,22,729-733.
  18. Morales, A. J.,Haubrich, R. H.,Hwang, J. Y.,Asakura, H.,Yen, S. S.(1998).The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women.Clin. Endocrinol.,49,421-432.
  19. Nestler, J. E.,Barlascini, C. O.,Clore, J. N.,Blackard, W. G.(1988).Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men.J. Clin. Endocrinol. Metabol.,66,57-61.
  20. Nestler, J. E.,Clore, J. N.,Blackard, W. G.(1991).Metabolism and actions of dehydroepiandrosterone in humans.J. Steroid Biochem. Mol. Biol.,40,599-605.
  21. Ostojic, S. M.(2007).Yohimbine: the effects on body composition and exercise performance in soccer players.Res. Sports Med.,14,289-299.
  22. Parasrampuria, J.,Schwartz, K.,Petesch, R.(1998).Quality control of dehydroepiandrosterone dietary supplement products.J. Am. Med. Assoc.,280,1565.
  23. Svec, F.,Porter, J. R.(1998).The actions of exogenous dehydroepiandrosterone in experimenatl animals and humans.Proc. Soc. Exp. Biol. Med.,218,174-191.
  24. Usiskin, K. S.,Butterworth, S.,Clore, J. N.,Arad, Y.,Ginsberg, H. N.,Blackard, W. G.,Nestler, J. E.(1990).Lack of effect of dehydroepiandrosterone in obese men.Int. J. Obes.,14,457-463.
  25. Villareal, D. T.,Holloszy, J. O.,Kohrt, W. M.(2000).Effects of DHEA replacement on bone mineral density and body composition in elderly women and men.Clin. Endocrinol.,53,561-568.
  26. Vogiatzi, M. G.,Boeck, M. A.,Vlachopapadopoulou, E.,el-Rashid, R.,New, M. I.(1996).Dehydroepiandrosterone in morbidly obese adolescents: effects on weight, body composition, lipids, and insulin resistance.Metabolism,45,1011-1015.
  27. Von Muhlen, D.,Laughlin, G. A.,Kritz-Silverstain, D.,Bergstrom, J.,Bettencourt, R.(2008).Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial.Osteoporos. Int.,19,699-707.
  28. Wallace, M. B.,Lim, J.,Cutler, A.,Bucci, L.(1999).Effects of dehydroepiandrosterone vs. androstenedione supplementation in men.Med. Sci. Sports Exerc.,31,1788-1792.
  29. Welle, S.,Jozefowicz, R.,Statt, M.(1990).Failure of dehydroepiandrosterone to influence energy and protein metabolism in humans.J. Clin. Endocrinol. Metab.,71,1259-1264.
  30. Wilmore, J. H.,Behnke, A. R.(1969).An anthropometric estimation of body density and lean body weight in young men.J. Appl. Physiol.,27,25-31.
  31. Wolf, O. T.,Neumann, O.,Hellhammer, D. H.,Geiben, A. C.,Strasburger, C. J.,Dressendorfer, R. A.,Pirke, K. M.,Kirschbaum, C.(1997).Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men.J. Clin. Endocrinol. Metabol.,82,2363-2367.
  32. Yamada, Y.,Sekihara, H.,Omura, M.,Yanase, T.,Takayanagi, R.,Mune, T.,Yasuda, K.,Ishizuka, T.,Ueshiba, H.,Miyachi, Y.,Iwasaki, T.,Nakajima, A.,Nawata, H.(2007).Changes in serum sex hormone profiles after short-term low-dose administration of dehydroepiandrosterone (DHEA) to young and elderly persons.Endocrine J.,54,153-162.
  33. Yen, S. S.\Morales, A. J.,Khorram, O.(1995).Replacement of DHEA in aging men and women. Potential remedial effects.Ann. N. Y. Acad. Sci.,774,128-142.
Times Cited
  1. 王士綸(2010)。彈性高分子電解質溶液之低頻介電係數計算。臺灣大學物理研究所學位論文。2010。1-50。 
  2. 曾佳輝(2011)。減量訓練對唾液免疫球蛋白A、睪固酮及皮質醇濃度之影響。臺灣師範大學體育學系學位論文。2011。1-43。