Decline in Semen Quality in Men in Northern Taiwan between 2001 and 2010




Ching-Jen Li;Chii-Ruey Tzeng;Ruey-Yu Chen;Bor-Cheng Han;Ching-Ying Yeh;Ling-Chu Chien

Key Words

cohort effect ; semen ; sperm motility


The Chinese Journal of Physiology

Volume or Term/Year and Month of Publication

預刊文章(2013 / 01 / 01)

Page #

1 - 11

Content Language


English Abstract

Semen quality is a key indicator of the male reproductive ability. The decline in semen quality has been debated for several decades. However, data on decline in semen quality might be inconsistent given factors such as geographical area, ethnicity, environmental exposure and lifestyle changes. This study aimed to provide information on the semen quality of men in Northern Taiwanese. We recruited 7,187 male participants between 2001 and 2010 from a reproductive medical center. The age of the participants ranged from 26 to 57 years, with a mean age of 36.9 ± 4.77 years. Semen analysis was performed through standardized methods outlined in the World Health Organization laboratory manual. Increasing age (per year) was significantly and negatively associated with semen volume (1.006 ml), progressive sperm motility, rapid progressive sperm motility and sperm with normal morphology (reduction by 1.010%, 1.013% and 1.002% per year, respectively). In addition, sperm concentration, semen volume, number of sperms, progressive sperm motility, rapid progressive sperm motility, and sperm with normal morphology were significantly reduced annually by 1.013 × 10^6/ml, 1.015 ml, 1.028 × 10^6, 1.021 %, 1.017% and 1.016%, respectively). Age-period-cohort analyses revealed that age and cohort had effects on reduction of the progressive and rapid progressive sperm motility. Moreover, all the sperm parameter values were significantly reduced annually. Our findings provide useful information for clinical practice and public health investigations of male reproductive health.

Topic Category 醫藥衛生 > 基礎醫學
  1. Lin, J.F.,Lin, Y.H.,Liao, P.C.,Lin, Y.C.,Tsai, T.F.,Chou, K.Y.,Chen, H.E.,Tsai, S.C.,Hwang, T.I.(2014).Induction of testicular damage by daily methamphetamine administration in rats.Chinese J. Physiol.,57,19-30.
  2. Becker, S.,Berhane, K.(1997).A meta-analysis of 61 sperm count studies revisited.Fertil. Steril.,67,1103-1108.
  3. Carlsen, E.,Giwercman, A.,Keiding, N.,Skakkebaek, N.E.(1992).Evidence for decreasing quality of semen during past 50 years.BMJ,305,609-613.
  4. Cocuzza, M.,Athayde, K.S.,Agarwal, A.,Sharma, R.,Pagani, R.,Lucon, A.M.,Srougi, M.,Hallak, J.(2008).Age-related increase of reactive oxygen species in neat semen in healthy fertile men.Urology,71,490-494.
  5. Dostal, L.A.,Chapin, R.E.,Stefanski, S.A.,Harris, M.W.,Schwetz, B.A.(1988).Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults.Toxicol. Appl. Pharmacol.,95,104-121.
  6. Elzanaty, S.(2007).Association between age and epididymal and accessory sex gland function and their relation to sperm motility.Arch. Androl.,53,149-156.
  7. Gaskins, A.J.,Colaci, D.S.,Mendiola, J.,Swan, S.H.,Chavarro, J.E.(2012).Dietary patterns and semen quality in young men.Hum. Reprod.,27,2899-2907.
  8. Gollenberg, A.L.,Liu, F.,Brazil, C.,Drobnis, E.Z.,Guzick, D.,Overstreet, J.W.,Redmon, J.B.,Sparks, A.,Wang, C.,Swan, S.H.(2010).Semen quality in fertile men in relation to psychosocial stress.Fertil. Steril.,93,1104-1111.
  9. Guo, Y.L.,Hsu, P.C.,Hsu, C.C.,Lambert, G.H.(2000).Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans.Lancet,356,1240-1241.
  10. Hsu, J.F.,Lee, C.C.,Su, H.J.,Chen, H.L.,Yang, S.Y.,Liao, P.C.(2009).Evaluation of background persistent organic pollutant levels in human from Taiwan: polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls.Environ. Int.,35,2009.
  11. Huang, L.P.,Lee, C.C.,Hsu, P.C.,Shih, T.S.(2011).The association between semen quality in workers and the concentration of di(2-ethylhexyl) phthalate in polyvinyl chloride pellet plant air.Fertil. Steril.,96,90-94.
  12. Itoh, N.,Kayama, F.,Tatsuki, T.J.,Tsukamoto, T.(2001).Have sperm counts deteriorated over the past 20 years in healthy, young Japanese men? Results from the Sapporo area.J. Androl.,22,40-44.
  13. Jedrzejczak, P.,Taszarek-Hauke, G.,Hauke, J.,Pawelczyk, L.,Duleba, A.J.(2008).Prediction of spontaneous conception based on semen parameters.Int. J. Androl.,31,499-507.
  14. Jensen, T.K.,Carlsen, E.,Jorgensen, N.,Berthelsen, J.G.,Keiding, N.,Christensen, K.,Petersen, J.H.,Knudsen, L.B.,Skakkebaek, N.E.(2002).Poor semen quality may contribute to recent decline in fertility rates.Hum. Reprod.,17,1437-1440.
  15. Jorgensen, N.,Andersen, A.G.,Eustache, F.,Irvine, D.S.,Suominen, J.,Petersen, J.H.,Andersen, A.N.,Auger, J.,Cawood, E.H.,Horte, A.,Jensen, T.K.,Jouannet, P.,Keiding, N.,Vierula, M.,Toppari, J.,Skakkebaek, N.E.(2001).Regional differences in semen quality in Europe.Hum. Reprod.,16,1012-1019.
  16. Kidd, S.A.,Eskenazi, B.,Wyrobek, A.J.(2001).Effects of male age on semen quality and fertility: a review of the literature.Fertil. Steril.,75,237-248.
  17. Kuo, H.W.,Wang, C.S.,Lai, J.S.(1997).Semen quality in workers with long-term lead exposure: a preliminary study in Taiwan.Sci. Total Environ.,204,289-292.
  18. Li, C.J.,Yeh, C.Y.,Chen, R.Y.,Tzeng, C.R.,Han, B.C.,Chien, L.C.(2015).Biomonitoring of blood heavy metals and reproductive hormone level related to low semen quality.J. Hazard. Mater.,300,815-822.
  19. Li, Y.,Lin, H.,Ma, M.,Li, L.,Cai, M.,Zhou, N.,Han, X.,Bao, H.,Huang, L.,Zhu, C.,Li, C.,Yang, H.,Rao, Z.,Xiang, Y.,Cui, Z.,Ao, L.,Zhou, Z.,Xiong, H.,Cao, J.(2009).Semen quality of 1346 healthy men, results from the Chongqing area of southwest China.Hum. Reprod.,24,459-469.
  20. Lu, Y.Y.,Chen, M.L.,Sung, F.C.,Wang, P.S.,Mao, I.F.(2007).Daily intake of 4-nonylphenol in Taiwanese.Environ. Int.,33,903-910.
  21. Lung, S.C.,Chen, C.F.,Hu, S.C.,Bau, Y.P.(2003).Exposure of Taiwan residents to polychlorinated biphenyl congeners from farmed, ocean-caught, and imported fish.Environ. Sci. Technol.,37,4579-4585.
  22. Merzenich, H.,Zeeb, H.,Blettner, M.(2010).Decreasing sperm quality: a global problem?.BMC Public Health,10,24.
  23. Mukhopadhyay, D.,Varghese, A.C.,Pal, M.,Banerjee, S.K.,Bhattacharyya, A.K.,Sharma, R.K.,Agarwal, A.(2010).Semen quality and age-specific changes: a study between two decades on 3,729 male partners of couples with normal sperm count and attending an andrology laboratory for infertility-related problems in an Indian city.Fertil. Steril.,93,2247-2254.
  24. Paasch, U.,Grunewald, S.,Kratzsch, J.,Glander, H.J.(2010).Obesity and age affect male fertility potential.Fertil. Steril.,94,2898-2901.
  25. Paulsen, C.A.,Berman, N.G.,Wang, C.(1996).Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform.Fertil. Steril.,65,1015-1020.
  26. Rowe, P.J.,Hargreave, T.B.,Mellows, H.J.,Comhaire, F.H.(1993).WHO Manual for the Standardized Investigation and Diagnosis of the Infertile Couple.Cambridge, United Kingdom:Cambridge University Press.
  27. Rybar, R.,Kopecka, V.,Prinosilova, P.,Markova, P.,Rubes, J.(2011).Male obesity and age in relationship to semen parameters and sperm chromatin integrity.Andrologia,43,286-291.
  28. Schwartz, D.,Mayaux, M.J.,Spira, A.,Moscato, M.L.,Jouannet, P.,Czyglik, F.,David, G.(1983).Semen characteristics as a function of age in 833 fertile men.Fertil. Steril.,39,530-535.
  29. Seo, J.T.,Rha, K.H.,Park, Y.S.,Lee, M.S.(2000).Semen quality over a 10-year period in 22,249 men in Korea.Korea. Int. J. Androl.,23,194-198.
  30. Sharpe, R.M.(2000).Lifestyle and environmental contribution to male infertility.Brit. Med. Bull.,56,630-642.
  31. Singh, N.P.,Muller, C.H.,Berger, R.E.(2003).Effects of age on DNA double-strand breaks and apoptosis in human sperm.Fertil. Steril.,80,1420-1430.
  32. Sloter, E.,Schmid, T.E.,Marchetti, F.,Eskenazi, B.,Nath, J.,Wyrobek, A.J.(2006).Quantitative effects of male age on sperm motion.Hum. Reprod.,21,2868-2875.
  33. Sripada, S.,Townend, J.,Campbell, D.,Murdoch, L.,Mathers, E.,Bhattacharya, S.(2010).Relationship between semen parameters and spontaneous pregnancy.Fertil. Steril.,94,624-630.
  34. Swan, S.H.,Elkin, E.P.,Fenster, L.(1997).Have sperm densities declined? A reanalysis of global trend data.Environ. Health Perspect.,105,1228-1232.
  35. Swan, S.H.,Elkin, E.P.,Fenster, L.(2000).The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996.Environ. Health Perspect.,108,961-966.
  36. Telišman, S.,Čolak, B.,Pizent, A.,Jurasovié, J.,Cvitković, P.(2007).Reproductive toxicity of low-level lead exposure in men.Environ. Res.,105,256-266.
  37. Vujkovic, M.,de Vries, J.H.,Dohle, G.R.,Bonsel, G.J.,Lindemans, J.,Macklon, N.S.,van der Spek, P.J.,Steegers, E.A.,Steegers-Theunissen, R.P.(2009).Associations between dietary patterns and semen quality in men undergoing IVF/ICSI treatment.Hum. Reprod.,24,1304-1312.
  38. Wu, S.J.,Pan, W.H.,Yeh, N.H.,Chang, H.Y.(2011).Trends in nutrient and dietary intake among adults and the elderly: from NAHSIT 1993-1996 to 2005-2008.Asia Pac. J. Clin. Nutr.,20,251-265.
  39. Zhu, Q.X.,Meads, C.,Lu, M.L.,Wu, J.Q.,Zhou, W.J.,Gao, E.S.(2011).Turning point of age for semen quality: a population-based study in Chinese men.Fertil. Steril.,96,572-576.
Times Cited
  1. 蘇珊玉,謝宜庭(2019)。中醫對於男性不孕精液分析的中醫微觀辨證與治療。中醫婦科醫學雜誌,23,14-20。