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在迴歸分析中共變數測量誤差的偏差效應

Bias Effect of Covariate Measurement Errors in Regression Analysis

摘要


本文討論在迴歸分析中,共變數測量誤差所造成的偏差效應。我們證明測量誤差可造成各種不同的偏差效應。因此自然估計式(naive estimator)可能低估,亦可能高估參數,此現象並不同於單變數線性迴歸的衰減效應(effect of attenuation)。在線性及logistic迴歸上我們作偏差分析。我們證明了若測量誤差在若干參數下的線性迴歸造成低估效應時,則其在一樣參數下的logistic迴歸上之低估效應將更強。本文也證明在測量誤差項的共變異數矩陣之估計是相同下,線性迴歸中某動差校正估計與迴歸插補校正估計法是相同的。我們做了模擬探討且看出了不同的效應,也以實例來探討測量誤差對參數估計的影響。

並列摘要


We study the effect of measurement error in regression analysis, in which multiple covariate variables are not precisely measured. When covariate variables are measured with errors, we show that measurement errors may lead to various effects and hence the naive estimator may either under- or over-estimate the regression coefficients. This is different from the effect of attenuation under simple linear regression. Bias analyses are conducted for linear and logistic regression. We show that if in linear regression with certain parameters the measurement error effect is under-estimation, then the underestimation is stronger in logistic regression under the same parameters. We study a method of moments and the regression calibration estimator and show that these two consistent estimators are asymptotically equivalent in linear regression. Intensive simulation studies are presented and we show situations for various effects. We demonstrate the methods by data from an epidemiologic study.

參考文獻


Carroll, R. J.,Ruppert, D.,Stefanski, L. A.(1995).Nonlinear Measurement Error Models.Chapman and Hall.
Chen, C. L.,Van Ness, J. W.(1998).Statistical Regression with Measurement Error.Arnold, London:Oxford University Press.
Cook, J.,Stefanski, L. A.(1995).A simulation extrapolation method for parametric measurement error models.Journal of the American Statistical Association.89,1314-1328.
Fuller, W. A.(1987).Measurement Error Model.New York:John Willey and Sons.
Huang, Y.,Wang, C. Y.(2001).Consistent functional methods for logistic regression with error in covariates.Journal of the American Statistical Association.96,1469-1482.

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