Angiomyofibroblastoma of the Vulva

Translated Titles





許逸欣(I-Hsin Hsu);張廷禎(Ting-Chen Chang);吳振都(Chen-Tu Wu);陳瑞堅(Ruey-Jien Chen);周松男(Song-Nan Chow)

Key Words

Angiomyofibroblastoma ; Case reports ; Soft tissue neoplasms ; Vulva


Journal of the Formosan Medical Association

Volume or Term/Year and Month of Publication

103卷6期(2004 / 06 / 01)

Page #

467 - 471

Content Language


English Abstract

Angiomyofibroblastoma is a rare, recently described, distinctive benign mesenchymal tumor that occurs mainly in the vulvar region of premenopausal women. We report a case of angiomyofibroblastoma of the vulva. A 45-year-old woman reported a small, painless nodule on the left vulva which rapidly enlarged during the 6 months before she visited the hospital. Local examination showed a pedunculated, mobile mass on the superior aspect of the left labium majus (13 x 12 x 10 cm) with elastic texture. Left vulvectomy was performed and the excised specimen revealed a well-defined and multilobulated tumor with edematous changes on gross examination. Microscopically, the tumor had alternate hyper- and hypocellular areas characterized by benign-looking round- to spindle-shaped cells with eosinophilic cytoplasm. The tumor cells were admixed with scattered thin-walled vessels in an edematous stroma. Immunohistochemical analysis was diffusely positive for desmin, estrogen receptor and progesterone receptor; reactive in small focus for actin; and negative for S-100 and CD34. Angiomyofibroblastoma, a mesenchymal tumor, was diagnosed. The postoperative course was smooth with no recurrence during the following 8 months. Simple excision for angiomyofibroblastoma is recommended because local recurrence or metastasis has not been reported.

Topic Category 醫藥衛生 > 醫藥衛生綜合