Risk Factors for Hemodynamically-Unrelated Cystic Periventricular Leukomalacia in Very Low Birth Weight Premature Infants

極低體重早産兒與血液動力學無關之囊狀腦室周圍白質軟化的危險因子

鍾美勇(Mei-Yung Chung) ； 方博炯(Po-Chiung Fang) ； 鍾景宏(Ching-Hung Chung) ； 黃崇濱(Chung-Bin Huang) ； 歐陽美慧(Mei-Hui Ouyang) ； 陳志誠(Chih-Cheng Chen)

《Journal of the Formosan Medical Association》 104卷8期 (2005/08) Pp. 571-577

https://doi.org/10.29828/JFMA.200508.0005

並列摘要

Background and Purpose: Periventricular leukomalacia (PVL) is one of the most important complications of prematurity but its cause remains unclear. This study investigated the risk factors for hemodynamically-unrelated cystic PVL in very low birth weight (VLBW) premature infants.
Methods: VLBW premature infants admitted to the neonatal intensive care unit from 1998 through 2002 were included in this retrospective study Infants who had congenital lethal anomalies or who tied before a cranial scan could be done were excluded All VLBW infants received serial cranial ultrasound. examinations to screen for cystic PVL during hospitalization Infants with cystic PVL were divided into those with or without a hemodynamic event of sufficient seventy to potentially cause cystic PYL. The charts of all inc1uded infants were reviewed and relevant clinical parameters were analyzed.
Results: Cystic PVL occurred in 20 VLBW infants (6.9%) during the study period Four of these infants (20%) had hemodynamic events before the development of cystic PVL and 16 (80%)ad hemodynamically-unrelated cystic PVL Univariate analysis showed that infants with hemodynmodyamy-unrelated cystic PVL were more, likely to have symptomatic patent ductus arteriosus (PDA) [p＜0.01] and bronchopulmonary dysplasa (BPD) [p＜0.01] However logistic regression indicated VLBW premature infants with BPD combined with symptomatic PDA (odds ratio 8.92; 95% confidence interval, 2.55-31.20; p＜0.01) were at greatest risk for development o hemodynamically-unrelated cystic PVL.
Conclusion: BPD and symptomatic PDA were more common in infants with hemodynamically unrelated cystic PVL although the reasons for these associations were unclear Serial cranial scans are strongly suggested for VLBW premature infants with BPD and symptomatic PDA to screen for the development of cystic PVL.

並列關鍵字

Bronchopulmonary dysplasia ； Patent ductus arteriosus ； Periventricular leukomalacia