Associations between Uterine Fibroids and Lifestyles Including Diet, Physical Activity and Stress: A Case-control Study in China

子宫肌瘤与膳食、体力活动及压力等生活方式之间的关系：中国的病例对照研究

Yuan He ； Qiang Zeng ； Sheng-Yong Dong ； Li-Qiang Qin ； Guo-wei Li ； Pei-yu Wang

《Asia Pacific Journal of Clinical Nutrition》 22卷1期 (2013/03) Pp. 109-117

https://doi.org/10.6133/apjcn.2013.22.1.07

摘要

本研究于2009年10月至2011年4月期间在中国采用病例对照研究探讨子宫肌瘤与膳食、体力活动及压力等生活方式之间的关系。共纳入73名子宫肌瘤患者和210未患肌瘤的正常女性。子宫肌瘤病例经超声或行子宫切除术进行诊断。采用自填式问卷收集女性膳食习惯，体力活动和压力等方面的信息。在控制年龄，孕次和产次等混杂因素后，进行逻辑回归分析，并计算疾病风险比值（OR）。结果发现蔬菜水果的摄入与职业性体力活动是子宫肌瘤的保护因素。对于绝经前女性，蔬菜水果的摄入（OR=0.5；95％CI：0.3，0.9）和职业性体力活动（OR=0.2；95％CI：0.1，0.6）能显着降低子宫肌瘤的风险；与之相反，BMI显着增加子宫肌瘤的患病风险（OR=1.2；95％CI：1.0，1.4）。这些关系在绝经后女性中没有统计学意义。研究表明在绝经前女性中，蔬菜水果的摄入和职业性体力活动是子宫肌瘤的保护因素，而高BMI是子宫肌瘤的危险因素。

關鍵字

子宫肌瘤 ； 膳食 ； 体力活动 ； 压力 ； 危险因素

並列摘要

This study was conducted to investigate the associations between uterine fibroids and lifestyles including diet, physical activity and stress from October 2009 to April 2011 in China. This case-control study composed of 73 women with uterine fibroids and 210 women without fibroids. Uterine fibroid cases were confirmed by ultrasound diagnosis or hysterectomy surgery. Information on women's dietary habits, physical activity and stress status were collected with a validated self-administered questionnaire. A logistic regression model was used to estimate the odds ratios (OR) after controlling for age, gravidity and parity. We found that vegetable and fruit intakes and occupational intensity played positive effects on uterine fibroids. For premenopausal women, vegetable and fruit intakes (OR=0.5; 95% CI: 0.3, 0.9) and occupational intensity (OR=0.2; 95% CI: 0.1, 0.6) significantly decreased the risk of fibroids; conversely, BMI significantly increased the risk (OR=1.2; 95% CI: 1.0, 1.4). However, the associations for postmenopausal women were not significant. Our findings suggested protective roles for vegetable and fruit intakes and occupational intensity on uterine fibroids, and supported the hypothesis that high BMI only increased the risk of uterine fibroids in premenopausal women.

並列關鍵字

uterine fibroid ； diet ； physical activity ； stress ； risk factors

參考文獻

Stewart EA. Uterine fibroids. Lancet. 2001;357:293-8.

Cramer SF, Patel A. The frequency of uterine leiomyomas. Am J Clin Pathol. 1990;94:435-8.

Okolo S. Incidence, aetiology and epidemiology of uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2008;22: 571-88.

Rice JP, Kay HH, Mahony BS. The clinical significance of uterine leiomyomas in pregnancy. Am J Obstet Gynecol. 1989;160:1212-6.

Garcia CR, Tureck RW. Submucosal leiomyomas and infertility. Fertil Steril. 1984;42:16-9.