The Association of Tea Consumption with Bladder Cancer Risk: A Meta-Analysis

喝茶与膀胱癌发生的整合分析

Shi-Hao Wu ； Fei Li ； Xiao Huang ； Qing-Sheng Hua ； Tao Huang ； Zhi-Le Liu ； Zhi-Xiang Liu ； Zhao-Fei Zhang ； Chun-Xian Liao ； Yuan-Xiang Chen ； Yu-Qiang Shi ； Ren-Chuang Zeng ； Min-Gen Feng ； Xin-Tai Zhong ； Zhao-Lin Long ； Wan-Long Tan ； Xin-Ji Zhang

《Asia Pacific Journal of Clinical Nutrition》 22卷1期 (2013/03) Pp. 128-137

https://doi.org/10.6133/apjcn.2013.22.1.15

摘要

目前有关喝茶与膀胱癌的关系在动物实验中已经得以证实，但在2001年一篇研究卻表明，喝茶与人类膀胱癌的发生无相关性。时至今日，为了能更精确的证明二者的相关性，我们对此进行整合分析。通过Pubmed检索工具收集1980年1月至2012年3月的所有关于喝茶与人类膀胱癌发生的前瞻性和回顾性研究，并且基于喝茶量的极值（最大值和最小值），利用随机效应模型计算RR和CI。最终纳入24篇相关文献（6篇为队列研究，18篇为病例－对照研究）进行整合分析。研究结果表明，对于未分类的茶而言，喝茶与膀胱癌发生无相关性（RR=1.09, 95%CI: 0.85-1.40）。但在亚组分析中，卻发现抽烟人群喝茶反而轻度增加膀胱癌的发生率（RR=1.77, 95%CI: 1.04-3.01）。喝红茶与膀胱癌的发生无相关性（RR=0.84, CI: 0.70-1.01）；但女性喝红茶可略減低膀胱癌发生的風險（RR=0.61, 95%CI: 0.38-0.98）；喝绿茶与膀胱癌的发生无相关性（RR=1.03, 95% CI: 0.82-1.31）。因此，由整合分析的結論為，抽烟人群喝茶可增加膀胱癌的发生，女性喝红茶則可降低膀胱癌的发生。

關鍵字

膀胱癌 ； 未分类茶 ； 红茶 ； 绿茶 ； 整合分析

並列摘要

The association between tea consumption and bladder cancer has been confirmed in several animal studies, but one epidemiological study in 2001 showed no association between them. In order to provide an accurate assessment of this, we conducted a meta-analysis on tea consumption and bladder cancer risk. Studies were identified by a literature search in PubMed from January 1980 to March 2012 and the reference lists of relevant studies. Random effect models were used to calculate summary relative risk estimates (RR) and their corresponding 95% confidence intervals (CI) based on high contrast to low intake values. Twenty-four publications (6 cohort studies and 18 case-control studies) based on consumption of overall tea, black tea, and green tea to bladder cancer risk were included in this analysis. For overall tea, the summary RR indicated no association between tea consumption and bladder cancer (RR=1.09, 95%CI: 0.85-1.40). In subgroup analyses, we found a moderate increase of bladder cancer risk in smoking group (RR=1.77, 95%CI: 1.04-3.01). In the black tea group, no statistically significant association was observed (RR=0.84, 95%CI: 0.70-1.01). Interestingly, in the subgroup of sex, a protective effect was observed between tea consumption and bladder cancer risk in female (RR=0.61, 95%CI: 0.38-0.98). For green tea group, there was no relationship associated with bladder cancer risk (RR=1.03, 95%CI: 0.82-1.31). In conclusion, our data suggest that high overall tea intake in smokers increased the risk of bladder cancer, and high black tea intake in female may reduce the risk of bladder cancer.

並列關鍵字

bladder cancer ； overall tea ； black tea ； green tea ； meta-analysis

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